利湿解毒汤加减联合重组人干扰素α-2B凝胶治疗高危型HPV感染临床研究  

Clinical Study on Modified Lishi Jiedu Decoction Combined with Recombinant Human Interferon α-2B Gel for High-Risk HPV Infection

作　　者：王屹丹 蒋文蔚[2] 李春香 朱文敏 邵美华 WANG Yidan;JIANG Wenwei;LI Chunxiang;ZHU Wenmin;SHAO Meihua

机构地区：[1]德清县中医院妇产科,浙江德清313200 [2]湖州市中心医院中医科,浙江湖州313000 [3]德清县中医院中医妇科,浙江德清青313200

出　　处：《新中医》2023年第2期111-114,共4页New Chinese Medicine

基　　金：2019年度湖州市第二批科技计划(2019GY88)。

摘　　要：目的:观察利湿解毒汤加减联合重组人干扰素α-2B凝胶治疗高危型人乳头瘤病毒(HPV)感染的临床疗效。方法:选取高危型HPV感染患者80例,按随机数字表法分为治疗组和对照组各40例。对照组给予重组人干扰素α-2B凝胶治疗,治疗组在对照组的基础上联合利湿解毒汤加减治疗。2组均连续治疗2个月。比较2组HPV转阴率、湿毒瘀结证证候评分及临床疗效。结果:治疗组总有效率为90.63%,对照组为65.63%,2组比较,差异有统计学意义(P<0.05)。治疗组HPV转阴率为92.50%,显著高于对照组的72.50%,组间比较,差异有统计学意义(P<0.05)。治疗前,2组带下量多、带下气臭、小腹胀痛、小便短赤、大便干燥等湿毒瘀结证证候评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项证候评分均较治疗前降低(P<0.05),且治疗组各项评分均低于对照组(P<0.05)。结论:利湿解毒汤加减联合重组人干扰素α-2B凝胶治疗高危型HPV感染,能提高HPV转阴率,进一步改善患者的中医证候,临床疗效更佳。Objective:To observe the clinical effect of modified Lishi Jiedu Decoction combined with Recombinant Human Interferon α-2B Gel for high-risk human papillomavirus(HPV)infection.Methods:A total of 80 cases of patients with high-risk HPV infection were selected and divided into the treatment group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with Recombinant Human Interferon α-2B Gel,and the treatment group was additionally treated with modified Lishi Jiedu Decoction based on the treatment of the control group.Both groups were treated for two months.The negative conversion rates of HPV,syndrome scores of dampness toxin stagnation syndrome and clinical effects in the two groups were compared.Results:The total effective rate was 90.63% in the treatment group and 65.63% in the control group,the difference being significant(P<0.05).The negative conversion rate of HPV was 92.50% in the treatment group,significantly higher than that of 72.50% in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of syndrome scores of dampness toxin stagnation syndrome including large leukorrhea amount,leukorrheal abnormal flavor,distending pain in lower abdomen,scanty dark urine and dry stool between the two groups(P>0.05);after treatment,the above syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05).Conclusion:Modified Lishi Jiedu Decoction combined with Recombinant Human Interferon α-2B Gel for high-risk HPV infection can improve negative conversion rates of virus,and further improve tradititonal Chinese medicine syndromes with better clinical effects.

关 键 词：高危型HPV感染 湿毒瘀结证 利湿解毒汤 重组人干扰素Α-2B凝胶 HPV转阴率 

分 类 号：R373.9[医药卫生—病原生物学]