定痫汤加味辅助治疗癫痫全面性发作的疗效及对脑电图间期放电、氧化应激的影响  

Curative Effect of Modified Dingxian Decoction in Adjuvant Therapy of Grand Mal Seizure and Its Effect on Interictal Epileptiform Activity on Electroencephalogram and Oxidative Stress

作　　者：王小娣[1] 赵东鹰[1] WANG Xiaodi;ZHAO Dongying

机构地区：[1]河南科技大学第二附属医院中医科,河南商洛阳471000

出　　处：《新中医》2023年第1期76-79,共4页New Chinese Medicine

基　　金：2022年度河南省医学科技攻关联合共建项目(LHGJ20220697)。

摘　　要：目的:观察定痫汤加味辅助治疗癫痫全面性发作的疗效及对脑电图间期放电(IEA)、氧化应激的影响。方法:选取84例癫痫全面性发作患者,按照信封法随机分为观察组43例与对照组41例。对照组接受常规治疗,观察组在对照组基础上给予定痫汤加味辅助治疗。比较2组临床疗效、IEA情况及不良反应,并比较2组治疗前后氧化应激指标[总抗氧化能力(T-AOC)、还原型谷胱甘肽(GSH-Px)、丙二醛(MDA)]、癫痫患者生活质量评定量表-31(QOLIE-31)评分及蒙特利尔认知评估量表(MOCA)评分。结果:观察组治疗总有效率88.37%,高于对照组70.73%(P<0.05)。观察组治疗后IEA情况优于对照组,且观察组IEA消失或下降超过50%的比例为81.40%,高于对照组56.10%(P<0.05)。治疗前,2组T-AOC、GSH-Px、MDA水平比较,差异无统计学意义(P>0.05);治疗后,2组T-AOC、GSH-Px水平较治疗前升高(P<0.05),MDA较治疗前降低(P<0.05),且观察组T-AOC、GSH-Px水平高于对照组(P<0.05),MDA水平低于对照组(P<0.05)。治疗前,2组QOLIE-31、MOCA评分比较,差异无统计学意义(P>0.05);治疗后,2组QOLIE-31评分均高于治疗前(P<0.05),且观察组高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(χ^(2)=0.611,P=0.435)。结论:采取定痫汤加味辅助治疗癫痫全面性发作患者效果良好,可明显改善患者IEA及氧化应激指标,且安全性较高。Objective:To observe the curative effect of modified Dingxian Decoction in adjuvant therapy of grand mal seizure and its effect on interictal epileptiform activity(IEA) on electroencephalogram and oxidative stress.Methods:A total of 84 cases of patients with grand mal seizure were selected and randomly divided into the observation group and the control group according to the envelope method,with43 and 41 cases in each group respectively.The control group was given conventional treatment,and the observation group was additionally treated with modified Dingxian Decoction based on the treatment of the control group.Clinical effects,IEA condition,and adverse reactions were compared between the two groups.The oxidative stress indexes including total antioxidant capacity(T-AOC),glutathione peroxidase(GSH-Px) and malondialdehyde(MDA),the Quality of Life in Epilepsy Inventory-31(QOLIE-31) Score,and the Montreal Cognitive Assessment(MOCA) Score were compared between the two groups before and after treatment.Results:The total effective rate was 88.37%in the observation group,higher than that of70.73%in the control group(P<0.05).After treatment,the IEA condition in the observation group was better than that in the control group,and the percentage of disappearance or decrease of IEA more than50%in the observation group was 81.40%,higher than that of 56.10%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of T-AOC,GSH-Px and MDA between the two groups(P>0.05).After treatment,levels of T-AOC and GSH-Px in the two groups were increased when compared with those before treatment(P<0.05),and MDA levels were decreased(P<0.05);levels of T-AOC and GSH-Px in the observation group were higher(P<0.05),and MDA level was lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of QOLTE-31 and MOCA between the two groups(P>0.05).After treatment,scores of QOLIE-31 in the two groups were hi

关 键 词：癫痫全面性发作 定痫汤 脑电图间期放电 氧化应激 认知功能 生活质量 

分 类 号：R277.7[医药卫生—中医学] R742.1