小儿消食颗粒联合双歧杆菌四联活菌片治疗小儿厌食症临床研究  

Clinical Study on Xiao’er Xiaoshi Granules Combined with Bifidobacterium Quadruple Viable Tablets for Anorexia in Children

作　　者：路鸣 邹胜男 LU Ming;ZOU Shengnan

机构地区：[1]安吉县妇幼保健院儿童保健部,浙江湖州313300 [2]安吉县妇幼保健院儿科,浙江湖州313300

出　　处：《新中医》2023年第1期125-128,共4页New Chinese Medicine

摘　　要：目的:观察小儿消食颗粒联合双歧杆菌四联活菌片治疗小儿厌食症的临床疗效及对胃肠激素的影响。方法:采用随机数字表法将268例厌食症患儿分为对照组与治疗组各134例。对照组给予双歧杆菌四联活菌片治疗,治疗组在对照组基础上联用小儿消食颗粒治疗。比较2组临床疗效及治疗前后中医证候评分、胃肠激素水平;比较2组疾病复发率及不良反应发生情况。结果:治疗组总有效率94.03%,高于对照组85.82%(P<0.05)。治疗后,2组中医证候积分、神经降压素(NT)均较治疗前降低(P<0.05),胃泌素(GAS)、胃动素(MLT)、酪神经肽(NPY)升高(P<0.05);治疗组治疗后中医证候积分及胃肠激素指标改善优于对照组(P<0.05)。2组均未发生任何不良反应。治疗组6个月、1年疾病复发率均低于对照组(P<0.05)。结论:小儿消食颗粒联合双歧杆菌四联活菌片治疗小儿厌食症疗效确切,能够有效调节患者胃肠激素分泌,减少疾病复发,安全性较高。Objective: To observe the clinical effect of Xiao’er Xiaoshi Granules combined with Bifidobacterium Quadruple Viable Tablets for anorexia in children and its effects on gastrointestinal hormones. Methods:A total of 268 cases of children with anorexia were divided into the control group and the treatment group according to the random number table method,with 134 cases in each group. The control group was treated with Bifidobacterium Quadruple Viable Tablets, and the treatment group was additionally treated with Xiao’er Xiaoshi Granules based on the treatment of the control group. Traditional Chinese medicine(TCM) syndrome scores and levels of gastrointestinal hormones before and after treatment,as well as clinical effects,were compared between the two groups. The disease recurrence rates and the incidence of adverse reactions in the two groups were compared. Results:The total effective rate was 94.03% in the treatment group,higher than that of 85.82% in the control group(P<0.05). After treatment,TCM syndrome scores and neurotensin(NT) in the two groups were decreased when compared with those before treatment(P<0.05),gastrin(GAS),motilin(MLT),and tyrosine neuropeptide(NPY) were increased(P<0.05);the improvement of TCM syndrome scores and gastrointestinal hormone indexes in the treatment group was better than that in the control group(P<0.05). There was no adverse reaction in the two groups. The disease recurrence rates within six months and one year in the treatment group were lower than those in the control group(P<0.05). Conclusion: The therapy of Xiao’er Xiaoshi Granules combined with Bifidobacterium Quadruple Viable Tablets has a defined curative effect in treating anorexia in children,and can effectively regulate gastrointestinal hormone secretion of patients, and reduce disease recurrence,with high safety.

关 键 词：小儿厌食症 小儿消食颗粒 双歧杆菌四联活菌片 胃肠激素 

分 类 号：R272[医药卫生—中医儿科学]