液相色谱-串联质谱法测定食品包装材料中14种内分泌干扰物的迁移量  

Determination of the migration of fourteen endocrine disruptors in food packaging materials by liquid chromatography-tandem mass spectrometry

作　　者：曹慧 姜侃 张慧 杨春 周学军 CAO Hui;JIANG Kan;ZHANG Hui;YANG Chun;ZHOU Xuejun(Zhejiang Institute of Product Quality and Safety Science,Hangzhou 310013,China;School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023,China)

机构地区：[1]浙江省产品质量安全科学研究院,杭州310013 [2]浙江科技学院生物与化学工程学院,杭州310023

出　　处：《分析试验室》2023年第1期57-64,共8页Chinese Journal of Analysis Laboratory

基　　金：浙江省市场监督管理局NQI项目(20210101,20200101)资助。

摘　　要：建立了液相色谱-串联质谱法同时测定食品包装材料中14种内分泌干扰物(双酚A、双酚E、双酚F、双酚S、双酚B、双酚Z、双酚AF、双酚AP、四溴双酚A、四氯双酚A、辛基酚、 4-正辛基酚、 4-壬基酚、4-正壬基酚)迁移量。样品经水、 4%乙酸、 10%乙醇、 50%乙醇、橄榄油、人工汗液和人工唾液浸泡,浸泡液经溶剂提取或Oasis HLB固相萃取柱净化,通过Waters AtlantisTMT3色谱柱分离,电喷雾负离子源和多反应监测模式测定,基质外标法定量。14种内分泌干扰物的线性相关系数为0.9901~0.9986,加标回收率为82.3%~108.7%,相对标准偏差为0.8%~6.8%,检出限为0.1~0.5μg/L,定量限为0.3~1.5μg/L。A method for the determination of the migration of 14 endocrine disruptors(bisphenol A, bisphenol E, bisphenol F, bisphenol S, bisphenol B, bisphenol Z, bisphenol AF, bisphenol AP, tetrabromobisphenol A, tetrachlorobisphenol A, octylphenol, 4-n-octylphenol, 4-nonylphenol and 4-n-nonylphenol) in food packaging materials by liquid chromatography-tandem mass spectrometry was developed. The samples were soaked in water, 4% acetic acid solution, 10% ethanol solution, 50% ethanol solution, olive oil, simulated sweat and simulated saliva. The soakings were purified by solvent extraction or Oasis HLB solid phase extraction. After separation by a Waters AtlantisTMT3column, the samples were determined by multiple reaction monitoring mode with electrospray negative ion source, and quantified by matrix external standard method. The linear correlation coefficients of 14 endocrine disruptors were 0.9901-0.9986, the recoveries were 82.3%-108.7% with the relative standard deviations of 0.8%-6.8%, the limits of detection were 0.1-0.5 μg/L and the limits of quantification were 0.3-1.5 μg/L.

关 键 词：液相色谱-串联质谱 内分泌干扰物 迁移 食品包装 

分 类 号：O657.63[理学—分析化学]