居家有氧运动对肝癌介入治疗患者负性情绪及血清BDNF、5-HT、NT-3水平的影响  

Effects of home-based aerobic exercise on negative emotions and serum BDNF,5-HT and NT-3 levels in patients with hepatocellular carcinoma undergoing interventional therapy

作　　者：蒋逢辰 周水平 陈世园 沈家宝 王庆华 戚龙菊 JIANG Fengchen;ZHOU Shuiping;CHEN Shiyuan(School of Medicine,Nantong University,Nantong,Jiangsu,226001)

机构地区：[1]南通大学医学院,江苏省南通市226001 [2]南通大学附属南通第三医院 [3]南通大学杏林学院 [4]南通大学实验动物中心

出　　处：《中国康复医学杂志》2023年第2期192-198,共7页Chinese Journal of Rehabilitation Medicine

基　　金：南通市科技局资助项目(MS12021039,MS12018020);国家级大学生创新创业训练计划(202110304036Z);南通大学博士科研启动基金(135420505015)。

摘　　要：目的:探讨居家有氧运动对行肝动脉栓塞化疗术(TACE)治疗的肝癌患者焦虑及抑郁情绪和血清BDNF、5-HT、NT-3的影响。方法:选取2018年1月—2019年12月行TACE治疗的183例肝癌患者,分为运动组91例和对照组92例。对照组接受常规介入科护理教育,运动组在此基础上接受3个月个性化的居家有氧运动。采用医院焦虑抑郁量表评估焦虑及抑郁程度,采用ELISA法检测患者血清BDNF、5-HT、NT-3含量。结果:运动组82例,对照组85例顺利完成研究。干预前,运动组与对照组焦虑和抑郁评分及血清BDNF、5-HT、NT-3含量无显著性差异(P>0.05)。干预后,运动组焦虑和抑郁评分为(8.46±3.34)和(9.95±2.67)分,显著低于对照组(10.08±4.33)和(12.26±3.09)分;运动组血清BDNF、5-HT和NT-3含量为(23428.74±9885.53)pg/ml、(3987.48±2297.55)ng/ml和(11325.43±3253.96)pg/ml,显著高于对照组(18887.79±8404.10)pg/ml、(3191.08±2163.46)ng/ml和(9235.05±3820.01)pg/ml。结论:居家有氧运动能够改善肝癌行TACE治疗患者的负性情绪,增加患者血清BDNF、5-HT、NT-3含量。Objective:To investigate the effects of home-based aerobic exercise on anxiety,depression and serum BDNF,5-HT,NT-3 level in patients undergoing transcatheter arterial chemoembolization(TACE) for liver cancer.Method:A total of 183 hepatocellular carcinoma patients who received TACE treatment from January 2018 to December 2019 were selected and divided into exercise group(91 patients) and control group(92 patients).The control group received routine interventional nursing education,and the exercise group received personalized home-based aerobic exercise for 3 months on this basis. The levels of anxiety and depression were assessed by hospital anxiety and depression scale,and the levels of serum BDNF,5-HT and NT-3 were detected by ELISA.Result: Eighty-two cases in the exercise group and 85 cases in the control group completed the study successfully. Before intervention,there were no significant differences in anxiety and depression scores and serum BDNF,5-HT and NT-3 levels between the exercise group and the control group(P>0.05). After intervention,the anxiety and depression scores of exercise group were 8.46 ±3.34 and 9.95 ±2.67,which were significantly lower than those of control group 10.08±4.33 and 12.26±3.09. Serum BDNF,5-HT and NT-3 levels in exercise group were(23428.74±9885.53)pg/ml,(3987.48±2297.55)ng/ml and(11325.43±3253.96)pg/ml,respectively and significantly higher than those of the control group(18887.79±8404.10)pg/ml,(3191.08±2163.46)ng/ml and(9235.05±3820.01)pg/ml,respectively.Conclusion: Home-based aerobic exercise can ease the negative emotions of hepatocarcinoma patients after TACE,and increase the levels of BDNF,5-HT and NT-3 in serum.

关 键 词：肝癌 居家有氧运动 焦虑 抑郁 细胞因子 

分 类 号：R493[医药卫生—康复医学] R735.7[医药卫生—临床医学]