瞬时受体电位M4通道在心血管疾病中的研究进展  

Research progress of transient receptor potential M4 channel in heart diseases

作　　者：李慧慧 李青蔓 张海英 刘辉 LI Hui-hui;LI Qing-man;ZHANG Hai-ying;LIU Hui(Hainan Provincial Key Laboratory of Tropical Brain Research and Translation,Haikou 570100,China)

机构地区：[1]海南省热带脑科学研究与转化重点实验室,海南省海口市570100

出　　处：《中国心血管病研究》2023年第2期97-102,共6页Chinese Journal of Cardiovascular Research

基　　金：国家自然科学基金(81560042)。

摘　　要：瞬时受体电位M4通道(transient receptor potential melastatin 4,TRPM4)为瞬时受体电位通道M型亚家族中的第四位成员,它是一种由细胞内Ca^(2+)激活的非选择性阳离子通道,在多个组织或器官中表达并发挥重要作用。TRPM4功能障碍可以引起癌症、神经系统疾病、心脏系统疾病等,它在心脏传导系统中的大量表达有可能是其引起心脏传导系统疾病的病理生理基础。TRPM4基因突变会引发遗传性心脏病,TRPM4基因的功能失常会引起心脏肥大以及缺血性心脏病,它们之间的病理生理机制极其复杂。本文就TRPM4在部分心脏疾病上的分子病理生理学研究现状做一综述。Transient receptor potential M4 channel(TRPM4)is the fourth member of the M-type subfamily of transient receptor potential channels.It is a non-selective cation channel activated by intracellular Ca^(2+).It is expressed in many tissues or organs and plays an important role.The dysfunction of TRPM4 can cause cancer,nervous system diseases,cardiac diseases,etc.Its large expression in the cardiac conduction system may be the pathophysiological basis of its causing cardiac conduction system diseases.TRPM4 gene mutation can cause hereditary heart disease;TRPM4 gene dysfunction can cause cardiac hypertrophy and ischemic heart disease;and the pathophysiological mechanisms between them are extremely complex.This article reviews the current research status of the molecular pathophysiology of TRPM4 in some cardiac diseases.

关 键 词：瞬时受体电位M4通道 遗传性心脏病 心脏肥大 缺血性心脏病 

分 类 号：R54[医药卫生—心血管疾病]