血清抑制素-A表达联合经腹部超声对宫外孕的诊断价值分析  

Diagnostic Value of Serum INH-A Expression Combined with Transabdominal Ultrasound in Ectopic Pregnancy

作　　者：沈晓丽 殷一飞 袁翠平[3] 栾炜[4] 尹剑兵 SHEN Xiao-li;YIN Yi-fei;YUAN Cui-ping;LUAN Wei;YIN Jian-bing(Department of Ultrasonography Lab,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Nanjing University of Chinese Medicine,Nanjing,Jiangsu,210014,China;Department of Ultrasonography Lab,Affiliated Hospital of Nantong University,Nantong,Jiangsu,226001,China;Department of Radiology,Jiangsu Provincial Hospital of Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine),Nanjing,Jiangsu,210029,China;Department of Radiology,Nanjing Drum Tower Hospital,Nanjing,Jiangsu,210008,China;Department of Radiology,The Second Affiliated Hospital of Nantong University(Nantong First People’s Hospital),Nantong,Jiangsu,226000,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院超声科,江苏南京210014 [2]南通大学附属医院超声科,江苏南通226001 [3]江苏省中医院(南京中医药大学附属医院)放射科,江苏南京210029 [4]南京市鼓楼医院放射科,江苏南京210008 [5]南通大学第二附属医院(南通市第一人民医院)放射科,江苏南通226000

出　　处：《现代生物医学进展》2023年第1期68-72,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81704196)。

摘　　要：目的:探讨血清抑制素-A表达联合经腹部超声对宫外孕的诊断价值。方法:选取我院2018年1月到2021年8月共收治的60例宫外孕患者作为研究对象,将其分为观察组,另取同期来我院体检的60例正常妊娠孕妇作为对照组,对所有孕妇均行血清抑制素-A(INH-A)、碱性磷酸酶(ALP)、β-人绒毛膜促性腺激素(β-HCG)检测,并对所有孕妇进行经腹部超声诊断。对比两组患者血清中ALP、β-HCG与INH-A表达水平,对比两组孕妇经腹部超声诊断结果,分析两组孕妇血清INH-A和经腹部超声单一诊断与联合诊断对宫外孕的诊断价值。结果:观察组孕妇ALP、β-HCG水平明显低于对照组,INH-A水平明显高于对照组(P<0.05);观察组孕妇无胎心搏动、宫内无孕囊、附件区有包块以及子宫内膜厚度小于10 mm情况明显高于对照组(P<0.05);联合诊断检出率明显高于血清抑INH-A和经腹部超声(P<0.05),联合诊断的误诊率和漏诊率明显低于血清INH-A和经腹部超声(P<0.05);联合诊断的准确度、敏感度明显高于其他两组单一检查方法(P<0.05),三种诊断方法在特异度、阳性预测值和阴性预测值方面的检测价值对比并无显著差异(P>0.05)。结论:应用血清抑制素-A表达联合经腹部超声诊断可提升宫外孕诊断的准确度与敏感性,因此可考虑对临床症状疑似宫外孕的患者应用两者联合诊断,提升诊断准确率。Objective:To investigate the diagnostic value of serum INH-A expression combined with transabdominal ultrasound in ectopic pregnancy.Methods:60 patients with ectopic pregnancy treated in our hospital from January 2018 to August 2021 were selected as the research object and divided into the observation group.Another 60 normal pregnant women who came to our hospital for physical examination in the same period were selected as the control group.All pregnant women were treated with serum inhibin-A(inh-a),alkaline phosphatase(ALP) β-Human chorionic gonadotropin(β-All pregnant women were diagnosed by transabdominal ultrasound.The expression levels of ALP,β-HCG and INH-A in serum of the two groups were compared,and the diagnostic results of transabdominal ultrasound were compared between the two groups.The diagnostic value of single diagnosis and combined diagnosis of serum INH-A and transabdominal ultrasound in ectopic pregnancy of the two groups were analyzed.Results:ALP of pregnant women in the observation group β-The level of hCG was lower than that of the control group,and the level of INH-A was higher than that of the control group(P0.05).Conclusion:The application of serum INH-A expression combined with transabdominal ultrasound diagnosis can improve the accuracy and sensitivity of ectopic pregnancy diagnosis,so it can be considered for patients with suspected clinical symptoms of ectopic pregnancy to apply the combined diagnosis,improve the diagnostic accuracy.

关 键 词：血清抑制素-A 经腹部超声 宫外孕 诊断价值 诊断准确率 

分 类 号：R714.22[医药卫生—妇产科学]