促渗剂对祛风活络喷雾剂体外经皮渗透效果的影响  

Influence of penetration enhancers on percutaneous penetration of Qufeng Huoluo Spray in vitro

作　　者：张新林 邱琼华 李隽永 陶晓静 张蓓 郑厚平 毛桂福 ZHANG Xin-lin;QIU Qiong-hua;LI Juan-yong;TAO Xiao-jing;ZHANG Bei;ZHENG Hou-ping;MAO Gui-fu(Liuzhou Traditional Chinese Medical Hospital(Liujcouh Si Ywcuengh YihYen),Liuzhou 545001,China)

机构地区：[1]柳州市中医医院(柳州市壮医医院),广西柳州545001

出　　处：《现代药物与临床》2022年第12期2729-2732,共4页Drugs & Clinic

基　　金：柳州市科技计划项目(2018BE10501)。

摘　　要：目的 筛选适宜祛风活络喷雾剂的促渗剂。方法 采用垂直式改良Franz扩散池考察1%、2%、3%的氮酮、薄荷脑、冰片3种促渗剂对祛风活络喷雾剂中岩白菜素的体外经皮促透作用。结果 岩白菜素累积透过量随着促渗剂浓度的增加而增加,透皮行为均符合零级方程,在高浓度条件下,薄荷脑的促透效果最优。结论 3%薄荷脑对祛风活络喷雾剂中岩白菜素促透效果优于同浓度的冰片和氮酮。Objective To screen suitable penetration enhancer for Qufeng Huoluo Spray. Methods Percutaneous permeationenhancing effects in vitro of bergenin in Qufeng Huoluo Spray with three permeation enhancers at different concentrations of 1%, 2%,and 3% were investigated on vertical modified Franz diffusion cell. Results The cumulative permeation amount of bergenin increased with the increase of the concentration of the permeation enhancers, and the permeation behaviors conformed to the Zero-order equation.Under the condition of high concentration, the permeation-enhancing effect of menthol was the best. Conclusion The penetration enhancement effects of 3% menthol on bergenin in Qufeng Huoluo Spray were better than those in borneol and azone at the same concentration.

关 键 词：祛风活络喷雾剂 岩白菜素 促渗剂 氮酮 薄荷脑 冰片 促透作用 

分 类 号：R283.6[医药卫生—中药学]