短链脂肪酸在炎症性肠病中的作用研究进展  

Research progress of short chain fatty acids in inflammatory bowel disease

作　　者：陈文轩 张哲 孙亚星 刘霞[1] 王斌斌 冯百岁(指导)[1] CHEN Wenxuan;ZHANG Zhe;SUN Yaxing;LIU Xia;WANG Binbin;FENG Baisui(Department of Gastroenterology,Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院消化内科,郑州450014

出　　处：《中国免疫学杂志》2023年第1期185-188,共4页Chinese Journal of Immunology

基　　金：河南省科技攻关项目(212102310803);河南省医学科技攻关计划省部共建项目(SBGJ2018042);郑州大学前沿交叉研究专项项目(XKZDQY201906);2021年度河南省医学科技攻关计划联合共建项目(LHGJ20210424,LHGJ20210409,LHGJ20210379)。

摘　　要：炎症性肠病(IBD)是肠道慢性炎症性疾病,主要包括溃疡性结肠炎(UC)和克罗恩病(CD),其确切病因和发病机制至今不明。SCFAs是一种羧酸,是一类对宿主免疫和能量状态具有多重影响的细菌代谢物。一元羧酸转运蛋白1(MCT1)和钠偶联的一元羧酸转运蛋白1(SMCT1)在肠上皮细胞吸收SCFAs中发挥关键作用。肠道稳态失衡是IBD的重要发病机制,SCFAs可通过激活GPCRs或抑制HDACs途径在调节肠道免疫细胞、维持黏膜完整性、调控细胞因子、提供细胞能量等维持肠道稳态方面发挥重要作用。本文就SCFAs在IBD中的作用研究进展进行综述。Inflammatory bowel disease(IBD)is a chronic inflammatory disease of intestinal tract,mainly including ulcerative colitis(UC)and Crohn’s disease(CD),whose exact etiology and pathogenesis are still unknown.SCFAs,a carboxylic acid,are a class of bacterial metabolites that have a pleiotropic effect on host immunity and energy state.Monocarboxylic acid transporter 1(MCT1)and sodium-coupled monocarboxylic acid transporter 1(SMCT1)play a key role in intestinal epithelial cell uptake of SCFAs.Intestinal homeostasis imbalance is an important pathogenesis of IBD.SCFAs play an important role in regulating intestinal immune cells,maintaining mucosal integrity,regulating cytokines,providing cellular energy and maintaining intestinal homeostasis by activating GPCRs or inhibiting HDACS pathway.This article reviews research progress of SCFAs in treatment of IBD.

关 键 词：炎症性肠病 短链脂肪酸 G蛋白偶联受体 组蛋白脱乙酰基酶 

分 类 号：R392[医药卫生—免疫学]