尿路致病性大肠杆菌与宿主相互作用的研究进展  

Research progress of uropathogenic Escherichia coli-host interactions

作　　者：周靖轩 袁春玲 向晨焱 王君(指导)[2] 邹黎黎[1] ZHOU Jingxuan;YUAN Chunling;XIANG Chenyan;WANG Jun;ZOU Lili(School of Basic Medical Science,China Three Gorges University,Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,Institute of Infection and Inflammation,Yichang 443000,China)

机构地区：[1]三峡大学基础医学院,肿瘤微环境与免疫治疗湖北省重点实验室,感染与炎症损伤研究所,宜昌443000 [2]三峡大学人民医院,宜昌443000

出　　处：《中国免疫学杂志》2023年第1期189-194,共6页Chinese Journal of Immunology

基　　金：国家青年基金项目(81903105);宜昌市医疗卫生科研项目基金项目(A19-301-50)。

摘　　要：泌尿系感染(UTI)是泌尿外科常见的感染性疾病,通常由尿路致病性大肠杆菌(UPEC)引起。UPEC入侵及定殖于尿路上皮细胞,造成泌尿系感染以及复杂的宿主免疫清除和病原体免疫逃逸,包括物理屏障的防御、中性粒细胞迁移、募集和吞噬以及细胞因子的分泌等。病原体与宿主之间复杂的免疫反应与免疫逃避是疾病发生发展的关键,也是UTI治疗的基础。本文针对最新的UTI中宿主-尿路致病大肠杆菌相互作用作一综述。Urinary tract infections(UTI)are common infectious diseases in urology which are usually caused by uropathogenic Escherichia coli(UPEC).The invading and colonizing processes of UPEC into the urothelial cells involve complex host immune clearance and pathogen immune escape,including immune barrier defence,migration,recruitment,phagocytosis of neutrophils and secretion of cytokines.The complex immune response and immune evasion between these pathogens and the host are the keys to the development of the disease and the basis for the treatment of UTI.This article reviews the host-UPEC interactions in the latest UTI.

关 键 词：尿路感染 尿路致病性大肠杆菌 免疫防御 免疫逃逸 

分 类 号：R378.21[医药卫生—病原生物学] R392.12[医药卫生—基础医学]