去除精浆中“胶冻状颗粒”对精液质量和宫腔内人工授精结局的影响  

Effects of removing "jelly-like particles" from seminal plasma on semen quality and outcome of intrauterine insemination

作　　者：伍玲园 范媛媛 雷丽君 文燕 董云玲 于娜 杨慧军 WU Lingyuan;FAN Yuanyuan;LEI Lijun;WEN Yan;DONG Yunling;YU Na;YANG Huijun(Reproductive Medicine Center,Shandong Provincial Maternal and Child Health Care Hospital,Jinan 250000,Shandong,China)

机构地区：[1]山东省妇幼保健院生殖医学中心,济南250000

出　　处：《中国性科学》2023年第2期9-12,共4页Chinese Journal of Human Sexuality

基　　金：山东省医药卫生科技发展计划项目(2019WS424)。

摘　　要：目的 探讨在宫腔内人工授精中使用短时离心法,去除液化完全后残留在精浆中的“胶冻状颗粒”,再行常规优化处理,分析其对精子回收率及妊娠结局的影响。方法 选取2017年1月至2020年12月山东省妇幼保健院生殖医学中心收治的215例患者作为研究对象,共350个周期,对其临床资料进行回顾性分析。随机分为两组,其中实验组127例205个周期,对照组88例145个周期。实验组采取短时离心法去除液化完全后残留在精浆中的“胶冻状颗粒”后再行常规优化处理,对照组仅行常规优化处理。比较两组优化后注入女方宫腔内前向运动精子数、精子回收率、临床妊娠率和累计临床妊娠率。结果 实验组前向运动精子数及精子回收率均显著高于对照组,差异具有统计学意义(P<0.05);实验组临床妊娠率和累计临床妊娠率稍高于对照组,但差异无统计学意义(P>0.05)。结论 在宫腔内人工授精中使用短时离心法去除液化完全后残留在精浆中的“胶冻状颗粒”再行常规优化处理,可提高优化后的前向运动精子数及精子回收率,进而可能会影响临床妊娠率和累计临床妊娠率。Objective To investgate the effect on the sperm recovery rate and pregnancy outcomes of using short-time centrifugation in intrauterine insemination to remove the "jelly-like particles" remaining in seminal plasma after complete liquefaction, and then optimizing the treatment routinely. Methods A total of 215 patients with 350 cycles admitted to the Reproductive Medicine Center of Shandong Provincial Maternal and Child Health Care Hospital from January 2017 to December 2020 were selected as study subjects, and their clinical data were retrospectively analyzed, and randomly divided into two groups, 127 cases with 205 cycles in the experimental group and 88 cases with 145 cycles in the control group. In the experimental group, the "jelly-like particles" remaining in the seminal plasma after complete liquefaction were removed by short-time centrifugation and then subjected to conventional optimization treatment, while in the control group, only conventional optimization treatment was performed. The number of inseminated forward-moving sperm, sperm recovery rate, clinical pregnancy rate and cumulative clinical pregnancy rate were compared between the two groups after optimization. Results The number of forward-moving sperm and sperm recovery rate in the experimental group were significantly higher than those in the control group, and the differences were statistically significant(P<0.05);the clinical pregnancy rate and cumulative clinical pregnancy rate in the experimental group were slightly higher than those in the control group, but there is no statistical differences(P>0.05). Conclusions The use of short-time centrifugation in intrauterine insemination to remove the "jelly-like particles" remaining in the seminal plasma after complete liquefaction and then routine optimization may improve the optimized forward-moving sperm and sperm recovery rate, which may affect the clinical pregnancy rate and cumulative clinical pregnancy rate.

关 键 词：宫腔内人工授精 精液 前向运动精子 精子回收率 临床妊娠率 累计临床妊娠率 

分 类 号：R697[医药卫生—泌尿科学]