血清白介素-10、肿瘤坏死因子-α与特发性少弱精子症患者精子DNA碎片指数的关系  

Relationship between serum IL-10, TNF-α and sperm DNA fragmentation index in patients with idiopathic oligoasthenospermia

作　　者：艾热提·阿皮孜[1] 阿不来提·买买提明[1] 布海丽且木·阿布都海拜尔 斯迪克江·尼亚孜 李晓东[1] AIRETI·Apizi;ABULAITI·Maimaitiming;BUHAILIWIEMU·Abudouhaibai′er;SIDIKEJIANG·Niyazi;LI Xiaodong(The Third Department of Urology and Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China;The Second Department of Urology and Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院泌尿外三科,乌鲁木齐830054 [2]新疆医科大学第一附属医院泌尿外二科,乌鲁木齐830054

出　　处：《中国性科学》2023年第2期16-20,共5页Chinese Journal of Human Sexuality

基　　金：新疆医科大学第一附属医院项目(2022-49)。

摘　　要：目的 观察特发性少弱精子症(IO)患者血清白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)和精子DNA碎片指数(DFI)水平,分析血清IL-10、TNF-α水平与患者DFI水平的关系。方法 选取2017年1月至2022年5月在新疆医科大学第一附属医院住院的126例IO患者作为观察组,纳入同期医院126例精液常规分析正常的男性作为对照组。两组均接受血清学检查和精液常规分析检查。比较两组血清IL-10、TNF-α和DFI水平,并采用双变量Pearson相关系数、线性回归模型分析血清IL-10、TNF-α水平与IO患者DFI水平的相关性。结果 观察组血清IL-10、TNF-α和DFI水平均高于对照组,差异具有统计学意义(P<0.05);经双变量Pearson相关系数检验,IO患者血清IL-10、TNF-α水平与DFI水平呈正相关(r>0,P<0.05);经线性回归分析结果显示,IO患者血清IL-10、TNF-α水平、精子浓度、精子活力与DFI水平有关(P<0.05),并得到方程:Y=-25.167+0.397X_(1)+0.295X_(2)+3.775X_(3)+6.049X_(4)。结论 IO患者血清IL-10、TNF-α水平与DFI水平存在一定的关系。Objective To observe the levels of serum interleukin-10(IL-10), tumor necrosis factor-α(TNF-α) and sperm DNA fragmentation index(DFI) in patients with idiopathic oligoasthenospermia(IO), and to analyze the relationship between the levels of serum IL-10, TNF-α and DFI of patients. Methods 126 patients with IO who were hospitalized in the First Affiliated Hospital of Xinjiang Medical University from January 2017 to May 2022 were selected as the observation group. In the same period, 126 patients with normal semen routine analysis were included as the control group. All the selected patients received serological examination and semen routine analysis. The levels of serum IL-10, TNF-α and DFI were compared between the two groups. Bivariate Pearson correlation coefficient and linear regression model were used to analyze the correlation between the levels of serum IL-10, TNF-α and DFI in IO patients. Results The levels of serum IL-10, TNF-α and DFI in the observation group were significantly higher than those in the control group, the difference was statistically significant(P<0.05);bivariate Pearson correlation coefficient test showed that the levels of serum IL-10 and TNF-α in patients with IO were positively correlated with DFI(r>0, P<0.05);linear regression analysis showed that the levels of serum IL-10, TNF-α, sperm concentration and sperm motility in patients with IO were positively correlated with DFI(P<0.05). The equation: Y=-25.167+0.397X_(1)+0.295X_(2)+3.775X_(3)+6.049X4. Conclusions The levels of serum IL-10, TNF-α in patients with IO are related to DFI.

关 键 词：特发性少弱精子症 精子DNA碎片指数 白介素-10 肿瘤坏死因子-Α 

分 类 号：R697[医药卫生—泌尿科学]