促排卵周期冻胚移植黄体支持中添加人绒毛膜促性腺激素对妊娠结局的影响  

The effect of HCG for luteal support in ovulation stimulation frozen-thawed embryo transfer cycles

作　　者：陆月红[1] 何尧[2] 陈惠娟[1] 马英英[1] 夏舟岚[1] LU Yuehong;HE Yao;CHEN Huijuan;MA Yingying;XIA Zhoulan(Center for Reproductive Medicine,Shaoxing Women and Children′s Hospital,Shaoxing 312000,Zhejiang,China;Department of Gynecology,Shaoxing Women and Children′s Hospital,Shaoxing 312000,Zhejiang,China)

机构地区：[1]浙江省绍兴市妇幼保健院生殖医学中心,浙江绍兴312000 [2]浙江省绍兴市妇幼保健院妇科,浙江绍兴312000

出　　处：《中国性科学》2023年第2期50-54,共5页Chinese Journal of Human Sexuality

基　　金：2021年浙江省卫生健康面上项目(2021KY1154)。

摘　　要：目的 探究促排卵内膜准备周期冻融胚胚移植(FET)黄体支持中添加人绒毛膜促性腺激素(HCG)对临床妊娠结局的影响。方法 回顾性分析2017年1月至2021年3月于绍兴市妇幼保健院生殖中心行促排卵方案准备内膜FET共491个周期的临床资料。根据FET后黄体支持是否添加HCG分为两组:常规组339个周期和HCG组152个周期。将两组患者的临床和实验室数据及FET临床妊娠结局进行统计分析。结果 HCG组着床率显著高于常规组(P<0.05),而新生儿出生体重显著低于常规组(P<0.05),两组临床妊娠率、活产率差异无统计学意义(P>0.05)。二元Logistic回归分析显示,年龄是影响临床妊娠结局的主要因素(P<0.001),黄体支持中是否添加HCG对临床妊娠率及活产率无显著影响(P>0.05)。结论 行促排卵方案内膜准备FET周期时,在常规黄体支持方案基础上添加HCG,对临床妊娠率及活产率无显著影响。Objective To explore the effect of human chorionic gonadotrophin(HCG) for luteal support in ovulation stimulation frozen-thawed embryo transfer(FET)cycles. Methods From January 2017 to March 2021 in the Center for Reproductive Medicine of Shaoxing Women and Children′s Hospital, 491 FET cycles with ovulation stimulation for endometrium preparation were included in this study. They were divided into two groups according to whether or not HCG was added to the corpus luteum support after FET:Routine group, 339 cycles, and HCG group, 152 cycles. The clinical data, laboratory data and pregnancy outcomes of FET cycles were analyzed retrospectively. Results The implantation rate was statistically higher in the HCG group than that in Routine group(P<0.05).The body weight of the newborns was significantly lower in the HCG group than that in Routine group(P<0.05). There was no significant difference in clinical pregnancy rate and live birth rate between the two groups(P>0.05). Binary Logistic regression model showed that age was the main influence factor for pregnancy outcomes;the effect of adding HCG for luteal support was not significant for clinical pregnancy rate and live birth rate. Conclusions For ovulation stimulation FET cycles, adding HCG for luteal support had no significant effect on clinical pregnancy rate and live birth rate.

关 键 词：冻胚移植 黄体支持 人绒毛膜促性腺激素 促排卵周期 

分 类 号：R711[医药卫生—妇产科学]