血清可溶性人类白细胞抗原G、白介素-17水平预测先兆流产患者保胎结局的研究  

Study on serum sHLA-G and IL-17 levels in predicting outcomes of fetal protection in patients with threatened abortion

作　　者：李霞 梁海珊[1] 杨飞飞 张丽[3] LI Xia;LIANG Haishan;YANG Feifei;ZHANG Li(Department of Clinical Laboratory,Hainan Traditional Chinese Medicine Hospital,Haikou 570100,Hainan,China;Department of Clinical Laboratory,Xianyang Central Hospital,Xianyang 712000,Shaanxi,China;Department of Obstetrics and Gynecology,Hainan Provincial Hospital of Traditional Chinese Medicine,Haikou 570100,Hainan,China)

机构地区：[1]海南省中医院检验科,海口570100 [2]咸阳市中心医院检验科,陕西咸阳712000 [3]海南省中医院妇产科,海口570100

出　　处：《中国性科学》2023年第2期80-83,共4页Chinese Journal of Human Sexuality

基　　金：海南省卫生健康行业科研项目(18A200165)。

摘　　要：目的 分析血清可溶性人类白细胞抗原G(sHLA-G)、白介素-17(IL-17)水平预测先兆流产患者保胎结局的价值。方法 选取2018年1月至2020年6月在海南省中医院接受保胎治疗的90例先兆流产患者作为研究对象,于治疗10d时根据保胎结局分为成功组(n=71)与失败组(n=19)。统计患者相关资料,分析治疗前血清sHLA-G、IL-17水平预测先兆流产患者保胎结局的价值。结果 90例患者中保胎失败19例,占21.11%;失败组与成功组血清sHLA-G、IL-17、孕酮(P)水平比较,差异具有统计学意义(P<0.05);受试者工作特征(ROC)曲线显示,先兆流产患者保胎治疗前血清sHLA-G、IL-17水平预测保胎失败风险的曲线下面积(AUC)均>0.80,均有较理想的预测价值,且联合预测价值最高。结论 保胎治疗前血清sHLA-G低表达、IL-17过表达可能提示先兆流产患者保胎失败风险高。Objective To analyze the value of serum soluble human leukocyte antigen G(sHLA-G) and interleukin-17(IL-17) levels in predicting outcomes of fetal protection in patients with threatened abortion. Methods 90 patients with threatened abortion who received fetal protection treatment in Hainan Provincial Hospital of Traditional Chinese Medicine from January 2018 to June 2020 were selected as the research objects. After 10 days of treatment, they were divided into success group(n=71) and failure group(n=19) according to the outcome of fetal protection. The value of serum sHLA-G and IL-17 levels before treatment in predicting the outcomes of fetal protection in patients with threatened abortion was analyzed. Results In 90 patients with threatened abortion, 19 cases was failure in fetal protection, accounting for 21.11%;the serum sHLA-G, IL-17 and progesterone(P) levels between failure group and success group was statistically significant(P<0.05). The receiver operating characteristic(ROC) curve showed that the area under curve(AUC) of serum sHLA-G and IL-17 levels in predicting the risk of failure of fetal protection in patients with threatened abortion before fetal protection treatment were all >0.80, with ideal predictive value. Conclusions The low expression of serum sHLA-G and the overexpression of IL-17 before fetal protection treatment may indicate the risk of failure of fetal protection in patients with threatened abortion.

关 键 词：先兆流产 可溶性人类白细胞抗原G 白介素-17 保胎结局 

分 类 号：R711[医药卫生—妇产科学]