过渡性B细胞分化发育及与疾病发生、发展关系的研究进展  

Research progress on transitional B cell differentiation and development and its correlation with the occurrence and development of diseases

作　　者：童琳 窦颖[1] TONG Lin;DOU Ying(Department of Hematology Oncology,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院血液肿瘤科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿童感染免疫重庆市重点实验室,重庆400014

出　　处：《现代免疫学》2023年第1期67-72,共6页Current Immunology

基　　金：国家自然科学基金青年科学基金项目(81601753)。

摘　　要：过渡性B细胞(transitional B cell)是近年来新发现的一类主要存在于外周、介于未成熟与成熟之间的B细胞类型。随着研究的不断深入,这一中间阶段细胞被发现是B细胞阴性选择的靶点和建立免疫耐受的检查节点,其分化发育与多种免疫性疾病关系密切。该文综合国内外大量文献资料,从过渡性B细胞的物理化学特征、相关分化发育过程和调控机制以及其与免疫性疾病发生、发展的关系等多个方面,对此类细胞进行全面而详细的阐述,为进一步的研究提供思路与理论基础。Transitional B cell is a newly discovered type of B cell that mainly exist in the periphery and with developmental characteristics between immature and mature B cell stages.Increasing evidence has suggested that cells in this intermediate stage are the targets of negative selection of B cells and the checkpoint for the establishment of immune tolerance.Transitional B cells are closely related to a variety of immune diseases.This review summarizes a large amount of domestic and foreign literature to provide a comprehensive and detailed description of this type of B cells from their physical and chemical characteristics,related signal pathways to their roles in the occurrence and development of immune diseases.This article aims to provide ideas and evidence for future research on transitional B cells.

关 键 词：过渡性B细胞 阴性选择 检查节点 免疫性疾病 

分 类 号：R392.12[医药卫生—免疫学]