苦参汤药浴联合黑光治疗寻常型银屑病的疗效研究  

Efficacy of Kushen Decoction Bath Combined with Black Lightin the Treatment of Psoriasis Vulgaris

作　　者：姜红伶 陈曦[1] 段行武[2] JIANG Hongling;CHEN Xi(Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 101100,China)

机构地区：[1]北京中医药大学东直门医院皮肤性病科,北京101100 [2]北京中医药大学东直门医院西区皮肤性病科,北京101100

出　　处：《河北医学》2023年第2期270-275,共6页Hebei Medicine

基　　金：国家自然科学基金委员会资助项目,(编号:81273755)。

摘　　要：目的:观察苦参汤药浴联合黑光治疗寻常型银屑病的疗效。方法:使用随机数字表采用简单随机分组方法将2020年2月至2021年2月我院收治的102例寻常型银屑病患者分为观察组与对照组各51例。对照组患者给予黑光治疗,观察组患者给予苦参汤药浴联合黑光治疗。比较两组患者临床疗效,比较治疗前后疾病症状[银屑病面积和严重程度指数(PASI)、瘙痒视觉模拟评分(VAS)]、血清相关因子[CC趋化因子配体20(CCL20))、转化生长因子β1(TGF-β1)、白细胞介素17(IL-17)、肿瘤坏死因子α(TNF-α)]、T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平。结果:治疗2周后,观察组临床总有效率(98.53%)高于对照组(88.24%)(P<0.05)。治疗2周后,两组PASI、VAS评分、血清相关因子(CCL20、IL-17、TNF-α、TGF-β1)及CD8+低于治疗前,且治疗前后差值的组间比较有统计学意义(P<0.05);两组CD3+、CD4+及CD4+/CD8+高于治疗前,且治疗前后差值的组间比较有统计学意义(P<0.05)。结论:苦参汤药浴联合黑光照射治疗相较于单纯的黑光照射治疗,对寻常银屑病疗效更显著,对调节机体炎症状态及免疫功能、减轻免疫损伤、促进皮肤修复等均有积极意义。Objective:To observe the efficacy of the Kushen decoction bath combined with black light in the treatment of psoriasis vulgaris.Methods:A simple random grouping method using a random number table was used to divide 102 patients with psoriasis admitted to our hospital from February 2020 to February 2021 into 51 cases each in the observation and control groups.The control group was given black light therapy,while the observation group was treated with a Kushen decoction bath combined with black light therapy.The clinical efficacy of the two groups of patients was compared,and the disease symptoms[Psoriasis Area and Severity Index(PASI),Pruritus Visual Analogue Scale(VAS)],serum-related factors[CC chemokine ligand 20(CCL20),transforming growth factorβ1(TGF-β1),interleukin 17(IL-17),tumor necrosis factor-α(TNF-α)]and levels of T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+)were compared before and after treatment.Results:After 2 weeks of treatment,the total clinical efficiency of the observation group(98.53%)was higher than that of the control group(88.24%)(P<0.05).After 2 weeks of treatment,the PASI score,VAS score,and levels of serum-related factors(CCL20,IL-17,TNF-α,TGF-β1)and CD8+in the two groups were lower than those before treatment,and the differences before and after treatment showed statistical significances between the groups(P<0.05).The levels of CD3+,CD4+,and CD4+/CD8+in both groups were higher compared to before treatment,and the differences before and after treatment were statistically significant between the groups(P<0.05).Conclusion:Compared with black light irradiation alone,Kushen decoction bath combined with black light irradiation therapy has a more significant efficacy on psoriasis vulgaris,and has a more positive significance in regulating the body’s inflammatory status and immune function,alleviating the immune damage and promoting the skin repair.

关 键 词：银屑病 苦参汤 黑光 炎性因子 免疫功能 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]