盐酸左西替利嗪片联合丙酸氟替卡松乳膏对湿疹患者的治疗效果观察  

Observation on therapeutic Effect of Levocetirizine Hydrochloride Tablets combined with Fluticasone Propionate Cream on Patients with Eczema

作　　者：丁治云 DING Zhiyun(Department of Dermatology,People's Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou People's Hospital,Zhengzhou Henan 450003,China)

机构地区：[1]河南中医药大学人民医院,郑州人民医院皮肤科,河南郑州450003

出　　处：《临床研究》2023年第3期69-72,共4页Clinical Research

摘　　要：目的探究湿疹患者采用盐酸左西替利嗪片+丙酸氟替卡松乳膏治疗效果。方法选郑州人民医院皮肤科2019年1月至2020年1月收治的150例湿疹患者为研究对象,将其依据随机数字表法分为对照组、观察组,各75例,分别应用丙酸氟替卡松乳膏治疗、盐酸左西替利嗪片+丙酸氟替卡松乳膏治疗。比较两组治疗效果、炎症因子[γ干扰素(IFN-γ)、肿瘤细胞坏死因子-α(TNF-α)]水平、免疫水平(IgA、IgG)、治疗前后皮损情况(皮损症状积分、皮损面积)、症状(鳞屑、浸润、疼痛、红斑、肥厚、水疱)消失时间及药物不良反应(口干、乏力、烧灼感、皮肤感染),随访1年,比较两组湿疹复发率。结果观察组治疗有效率(96.00%)高于对照组(85.33%),差异有统计学意义(P<0.05)。治疗后观察组IFN-γ、TNF-α水平均较对照组低,差异有统计学意义(P<0.05)。治疗后观察组IgA、IgG水平均较对照组高,差异有统计学意义(P<0.05)。治疗后观察组皮损症状积分水平较对照组低,皮损面积较对照组少,差异有统计学意义(P<0.05)。观察组鳞屑、浸润、疼痛、红斑、肥厚、水疱消失时间均较对照组短,差异有统计学意义(P<0.05)。观察组不良反应发生率(5.33%)与对照组(2.67%)相近,差异无统计学意义(P>0.05)。观察组1年复发率(6.67%)较对照组(18.67%)低,差异有统计学意义(P<0.05)。结论对湿疹患者应用盐酸左西替利嗪片+丙酸氟替卡松乳膏治疗,可提升治疗效果,减轻患者炎症反应程度,提升炎症反应清除能力,改善皮损症状,提升局部免疫症状,并未增加药物不良反应,同时降低1年复发率,效果理想。Objective To explore the therapeutic effect of levocetirizine hydrochloride tablets combined with fiuticasone propionate cream on patients with eczema.Methods A total of 150 patients with eczema admitted to the department of dermatology of Zhengzhou People’s Hospital from January 2019 to January 2020 were selected as the study subjects.They were divided into control group and observation group according to the method of random number table,with 75 patients in each group.They were treated with fiuticasone propionate cream and levocetirizine hydrochloride tablets combined with fiuticasone propionate cream respectively.The treatment effect and infiammatory factors[γinterferon(IFN-γ),tumor necrosis factor-α(TNF-α)],immune level(IgA,IgG),skin lesions before and after treatment(skin lesion symptom score,skin lesion area),symptoms(scale,infiltration,pain,erythema,hypertrophy,blister),disappearance time and adverse drug reactions(dry mouth,fatigue,burning sensation,skin infection)between the two groups were compared.For 1 year following up,the recurrence rate of eczema was compared between the two groups.Results The effective rate of treatment in the observation group(96.00%)was significantly higher than that in the control group(85.33%),the difference was statistically significant(P<0.05).The level of IFN-γand TNF-αin the observation group after treatment was lower than those in the control group,with statistically significant difference(P<0.05).After treatment,the levels of IgA and IgG in the observation group were significantly higher than those in the control group,the difference was statistically significant(P<0.05).After treatment,the score level of skin lesions in the observation group was lower than that in the control group,and the area of skin lesions was less than that in the control group,with a statistically significant difference(P<0.05).The disappearance time of scale,infiltration,pain,erythema,hypertrophy and blister in the observation group was shorter than those in the control group,with statist

关 键 词：湿疹 盐酸左西替利嗪片 丙酸氟替卡松乳膏 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]