左氧氟沙星联合头孢哌酮钠舒巴坦钠治疗老年肺炎的临床效果观察  

Clinical observation of levofloxacin combined with cefoperazone sodium and sulbactam sodium in the treatment of senile pneumonia

作　　者：曹静 CAO Jing(Xingcheng People's Hospital,Huludao 125100,China)

机构地区：[1]兴城市人民医院,125100

出　　处：《中国现代药物应用》2023年第3期114-116,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 观察左氧氟沙星联合头孢哌酮钠舒巴坦钠治疗老年肺炎的临床疗效。方法 118 例老年肺炎患者 , 按照治疗模式的不同分为对照组和观察组 , 每组 59 例。对照组采用头孢哌酮钠舒巴坦钠治疗 , 观察组在对照组治疗基础上联合左氧氟沙星治疗。比较两组治疗效果、治疗前后炎症指标及不良反应发生情况。结果 观察组治疗总有效率为 98.31%(58/59), 高于对照组的 86.44%(51/59), 差异有统计学意义 (P<0.05)。治疗后 , 观察组 C 反应蛋白 (CRP)(2.01±0.53)mg/L、白细胞计数 (WBC)(8.01±0.95)×109/L及 降 钙 素 原 (PCT)(1.74±0.83)ng/L, 均 低 于 对 照 组 的 (3.59±0.74)mg/L、(11.72±1.49)×109/L、(3.64±1.02)ng/L, 差异有统计学意义 (P<0.05)。观察组不良反应发生率为 5.08%(3/59), 与对照组的 8.47%(5/59)比较 , 差异无统计学意义 (P>0.05)。结论 老年肺炎患者采用左氧氟沙星联合头孢哌酮钠舒巴坦钠治疗可提升肺功能 , 改善炎症指标 , 用药安全 , 方案值得推荐。Objective To observe the clinical efficacy of levofloxacin combined with cefoperazone sodium and sulbactam sodium in the treatment of senile pneumonia. Methods A total of 118 senile patients with pneumonia were divided into a control group and an observation group according to the different treatment modes,with 59 cases in each group. The control group was treated with cefoperazone sodium and sulbactam sodium,and the observation group was treated with levofloxacin on the basis of the control group. The therapeutic effect,inflammation index before and after treatment, and the occurrence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 98.31% (58/59), which was higher than 86.44% (51/59) in the control group, and the difference was statistically significant (P<0.05). After treatment, the observation group had C-reactive protein (CRP) of (2.01±0.53) mg/L, white blood cell count (WBC)of (8.01±0.95)×10~9/L and procalcitonin (PCT) of (1.74±0.83) ng/L, which were lower than (3.59±0.74) mg/L,(11.72±1.49)×10~9/L and (3.64±1.02) ng/L in the control group, and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 5.08% (3/59), and the difference was not statistically significant when compared with 8.47% (5/59) in the control group (P>0.05). Conclusion Levofloxacin in combination with cefoperazone sodium and sulbactam sodium in the treatment of senile pneumonia can improve lung function, improve inflammatory indicators with high medication safety, which is worth recommending.

关 键 词：老年肺炎 左氧氟沙星 头孢哌酮钠舒巴坦钠 临床效果 

分 类 号：R563.1[医药卫生—呼吸系统]