沙参养胃汤治疗胃阴不足型慢性萎缩性胃炎的临床疗效观察  

Observation on clinical efficacy of Shashen Yangwei Decoction in the treatment of chronic atrophic gastritis with stomach-yin deficiency

作　　者：张莹 ZHANG Ying(Department of Traditional Chinese Medicine,Pulandian District Hospital of Traditional Chinese Medicine,Dalian 116200,China)

机构地区：[1]大连市普兰店区中医医院中医科,116200

出　　处：《中国现代药物应用》2023年第3期152-154,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析沙参养胃汤治疗胃阴不足型慢性萎缩性胃炎的临床疗效。方法 112例胃阴不足型慢性萎缩性胃炎患者,随机分为观察组和对照组,每组56例。对照组患者给予雷贝拉唑+阿莫西林+枸橼酸铋钾治疗,观察组患者在对照组基础上给予沙参养胃汤治疗。比较两组患者治疗效果、中医证候积分及白细胞介素-6(IL-6)、核转录因子p65(NF-κBp65)、胃泌素水平。结果 观察组患者治疗总有效率92.86%明显高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,两组患者胃脘胀痛、痞满烦闷、食少纳呆、嘈杂反酸积分比较,差异无统计学意义(P>0.05);治疗后,观察组患者胃脘胀痛积分(1.15±0.22)分、痞满烦闷积分(1.34±0.27)分、食少纳呆积分(1.14±0.26)分、嘈杂反酸积分(0.73±0.13)分均明显低于对照组的(1.73±0.26)、(1.85±0.31)、(1.69±0.30)、(1.07±0.16)分,差异有统计学意义(P<0.05)。治疗前,两组患者血清IL-6、NF-κBp65、胃泌素水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者血清IL-6(40.55±9.79)pg/ml、NF-κBp65(25.51±5.83)mg/L均明显低于对照组的(47.76±10.14)pg/ml、(30.42±6.65)mg/L,胃泌素(36.74±7.32)ng/L明显高于对照组的(31.53±6.54)ng/L,差异有统计学意义(P<0.05)。结论 在常规西药基础上应用沙参养胃汤治疗胃阴不足型慢性萎缩性胃炎患者,不仅能够提升其疗效,改善其症状,同时能够降低患者的炎性水平,促进胃动力,降低其癌变风险,临床可积极应用。Objective To analyze the clinical efficacy of Shashen Yangwei Decoction in the treatment of chronic atrophic gastritis with stomach-yin deficiency. Methods A total of 112 cases of chronic atrophic gastritis with stomach-yin deficiency were randomly divided into observation group and control group, with 56 cases in each group. Patients in the control group were treated with rabeprazole + amoxicillin + bismuth potassium citrate, and patients in the observation group were treated with Shashen Yangwei Decoction on the basis of the control group.The therapeutic effect, traditional Chinese medicine symptom score and levels of interleukin-6(IL-6), nuclear factor kappa B p65(NF-κBp65) and gastrin were compared between the two groups. Results The total effective rate of the observation group was 92.86%, which was significantly higher than 75.00% of the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in the scores of epigastric distension, fullness and boredom, anorexia, and noisy acid regurgitation between the two groups(P>0.05). After treatment, the epigastric distension score(1.15±0.22) points, fullness and boredom score(1.34±0.27) points, anorexia score(1.14±0.26) points, and noisy acid regurgitation(0.73±0.13) points in the observation group were significantly lower than(1.73±0.26),(1.85±0.31),(1.69±0.30), and(1.07±0.16) points in the control group, and the differences were statistically significant(P<0.05). Before treatment,there was no statistically significant difference between the two groups in terms of serum IL-6, NF-κBp65 and gastrin levels(P>0.05). After treatment, the serum IL-6(40.55±9.79) pg/ml and NF-κBp65(25.51±5.83) mg/L of patients in the observation group were significantly lower than(47.76±10.14) pg/ml and(30.42±6.65) mg/L in the control group, and the gastrin(36.74±7.32) ng/L was significantly higher than(31.53±6.54) ng/L in the control group. The differences were statistically significant(P<

关 键 词：胃阴不足型 慢性萎缩性胃炎 沙参养胃汤 雷贝拉唑 阿莫西林 枸橼酸铋钾 

分 类 号：R259[医药卫生—中西医结合]