新型5-氨基异噻唑衍生物的合成  

Synthesis of Novel 5-Amino-isothiazole Derivatives

作　　者：严映坤 李敏[1,3] 刘敏 曹镰义[1,3] 李文哲 黄敏 张晓梅 YAN Yingkun;LI Min;LIU Min;CAO Lianyi;LI Wenzhe;HUANG Min;ZHANG Xiaomei(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;School of Science,Xihua University,Chengdu 610039,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]西华大学理学院,四川成都610039 [3]中国科学院大学,北京100049

出　　处：《合成化学》2023年第2期146-153,共8页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21672208)。

摘　　要：以苯甲腈和乙腈为起始原料,在叔丁醇钾催化下,得到烯胺中间体,随后经过4步反应并在温和简单的条件下,以中等到良好的产率(74%~88%)合成新型5-氨基异噻唑衍生物,所有产物结构由^(1)H NMR,^(13)C NMR和HR-MS(ESI)表征。Benzonitrile and acetonitrile were used as starting materials and catalyzed by potassium tert-butoxide to obtain enamine intermediates, followed by a 4-step reaction to synthesise the final novel 5-aminoisothiazole derivatives. A series of novel 5-aminoisothiazole derivatives were synthesised in moderate to good yields(74%~88%) under mild and simple conditions. The structures of all products were confirmed by ^(1)H NMR,^(13)C NMR and HR-MS(ESI).

关 键 词：苯甲腈 乙腈 叔丁醇钾 5-氨基异噻唑 烯胺中间体 合成 

分 类 号：O626.29[理学—有机化学]