Pulmonary endogenous progenitor stem cell subpopulation:Physiology,pathogenesis,and progress  

作　　者：Di Liu Chufan Xu Lai Jiang Xiaoyan Zhu 

机构地区：[1]Department of Anesthesiology and Surgical Intensive Care Unit,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China [2]Department of Physiology,Navy Medical University,800 Xiangyin Road,Shanghai 200433,China

出　　处：《Journal of Intensive Medicine》2023年第1期38-51,共14页重症医学（英文）

基　　金：National Natural Science Foundation of China(Grant No:32171124,82072209,and 81772117);Shanghai Science and Technology Commission(Grant No:19XD1402600 and 21YF1428600).

摘　　要：Lungs are structurally and functionally complex organs consisting of diverse cell types from the proximal to distal axis.They have direct contact with the external environment and are constantly at risk of various injuries.Capable to proliferate and differentiate,pulmonary endogenous progenitor stem cells contribute to the maintenance of lung structure and function both under homeostasis and following injuries.Discovering candidate pulmonary endogenous progenitor stem cell types and underlying regenerative mechanisms provide insights into therapeutic strategy development for lung diseases.In this review,we reveal their compositions,roles in lung disease pathogenesis and injury repair,and the underlying mechanisms.We further underline the advanced progress in research approach and potential therapy for lung regeneration.We also demonstrate the feasibility and prospects of pulmonary endogenous stem cell transplantation for lung disease treatment.

关 键 词：Stem cell Lung diseases Lung injury Regeneration Repair 

分 类 号：R563[医药卫生—呼吸系统]