子宫巨噬细胞在正常妊娠及病理性妊娠中的作用  

Mechanism of Uterine Macrophages in the Normal Pregnancy and Pathological Pregnancy

作　　者：马丽娜[1] 张多加(审校) 吴效科 MA Li-na;ZHANG Duojia;WU Xiao-ke(Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院

出　　处：《国际妇产科学杂志》2023年第1期65-69,共5页Journal of International Obstetrics and Gynecology

基　　金：国家重点研发计划项目(2019YFC1709500);黑龙江省自然科学基金(LH2019H116)。

摘　　要：巨噬细胞(macrophages)是妊娠期母体子宫蜕膜中数量第二丰富的淋巴细胞,可分泌多种具有抗炎和促炎作用的细胞因子和趋化因子。巨噬细胞除作为主要抗原呈递细胞参与蜕膜免疫外,还在母胎界面免疫耐受的建立和维持、滋养细胞侵入、血管生成和螺旋动脉重塑以及凋亡细胞的吞噬中发挥关键作用。因此,巨噬细胞的细胞数量、极化和功能异常与妊娠并发症如流产、子痫前期和早产等密切相关。综述近年子宫巨噬细胞极化、功能及其在正常妊娠建立、维持和病理性妊娠中作用机制的最新研究进展,以期为从免疫角度探讨病理性妊娠发病机制及研发精准防治策略提供新的思路。Macrophages are the second most abundant lymphocyte in the maternal uterine decidua during pregnancy,which can secrete a variety of cytokines and chemokines with anti-inflammatory and pro-inflammatory effects.In addition to participating in decidual immunity as the main antigen presenting cells,macrophages play a key role in the establishment and maintenance of immune tolerance at the maternal-fetal interface,trophoblast invasion,angiogenesis,spiral artery remodeling and phagocytosis of apoptotic cells.Thus,abnormalities in cell number,polarization and function of macrophages are believed to be closely associated with pregnancy complications such as abortion,pre-eclampsia and preterm birth.In order to providing new insights into the pathogenesis of pathological pregnancy from the perspective of immunity and developing precise prevention and treatment strategies,this review focuses on the latest research achievements of the polarization and function of uterine macrophages and their mechanisms in the establishment and maintenance of normal pregnancy and pathological pregnancy in recent years.

关 键 词：巨噬细胞 子宫 免疫耐受 妊娠 先兆子痫 

分 类 号：R714.2[医药卫生—妇产科学]