下丘脑炎症在多囊卵巢综合征中的调节机制  

Regulation Mechanism of Hypothalamic Inflammation in Polycystic Ovary Syndrome

作　　者：孙畅 潘紫萌 赵珊珊 李婧 匡洪影(审校)[2] SUN Chang;PAN Zi-meng;ZHAO Shan-shan;LI Jing;KUANG Hong-ying(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,The First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科

出　　处：《国际妇产科学杂志》2023年第1期109-115,共7页Journal of International Obstetrics and Gynecology

基　　金：国家自然科学基金面上项目(82174422);黑龙江省博士后科研启动金(LBH-Q18119);黑龙江中医药大学研究生创新科研项目(2022yjscx015)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是引起育龄期女性生殖障碍和代谢异常的常见妇科疾病,临床表现具有异质性。下丘脑炎症是一种以小胶质细胞激活为主要病理改变的低度炎性病变,被认为是PCOS代谢、生殖及临床异质性的病理和生理基础。研究表明,下丘脑在调节并维持机体代谢稳态和生殖功能中发挥重要作用;通过下丘脑炎症的诱发途径,提出了碳水化合物和饱和脂肪酸的共同过量摄入是其主要诱因。此外,下丘脑炎症在PCOS相关代谢紊乱和生殖障碍的发生、发展中具有重要作用及其潜在诱发途径,提示下丘脑各神经元以及中枢与外周之间异常的信号转导是诱发PCOS相关病理改变的关键途径,这些途径有望为临床治疗PCOS提供新思路、新靶点。Polycystic ovary syndrome(PCOS)is a common gynecological disease among women of reproductive age.It causes reproductive disorders and metabolic abnormalities,which has heterogeneous clinical manifestations.Hypothalamic inflammation is a low-grade inflammatory disease with microglial activation as the main pathological change,which is considered as the pathological and physiological basis of PCOS metabolism,reproduction and clinical heterogeneity.Recent researches have clarified the crucial role of the hypothalamus in regulating and maintaining metabolic homeostasis and reproductive function.Through the induction pathway of hypothalamic inflammation,it is proposed that the common excessive intake of carbohydrates and saturated fatty acids is the main inducement.Furthermore,the important role of hypothalamic inflammation in the occurrence and development of PCOS related metabolic and reproductive disorders and the potential inducing pathways were described,and the abnormal signal transduction among hypothalamic neurons and between the center and periphery were considered as the key pathways to induce PCOS related pathological changes.These pathways are expected to provide new ideas and targets for clinical treatment of PCOS.

关 键 词：多囊卵巢综合征 下丘脑-垂体系统 炎症 代谢 胰岛素抗药性 

分 类 号：R711.75[医药卫生—妇产科学]