CX3CL1-CX3CR1轴参与小胶质细胞、神经元及其交互的调控  

The CX3CL1-CX3CR1 Axis Mediates the Crosstalk Between Microglia and Neurons

作　　者：李宁 王应[2] LI Ning;WANG Ying(Peking University Health Science Center,Beijing 100191,China;Department of Immunology,School of Basic Medical Sciences,and NHC Key Laboratory of Medical Immunology,Peking University,Beijing 100191,China)

机构地区：[1]北京大学医学部,北京100191 [2]北京大学基础医学院免疫学系,北京100191

出　　处：《生理科学进展》2023年第1期38-45,共8页Progress in Physiological Sciences

基　　金：北京大学医学部创新人才项目资助课题。

摘　　要：小胶质细胞与神经元在大脑生理状态或病理状态下都进行着广泛的双向通讯,其对于大脑稳态的建立具有重要作用。研究发现,趋化因子CX3CL1及其受体CX3CR1在小胶质细胞、神经元及其交互调控中起着重要作用,因此有可能成为多种神经退行性疾病、精神疾病等脑病理状态的新靶点。本文就近年来国内外研究CX3CL1-CX3CR1信号轴在小胶质细胞、神经元及其交互调控中的作用进行综述。Microglia and neurons have extensive bidirectional communication in both physiological and pathological brain states,which plays an important role in the establishment of brain homeostasis.It has been found that chemokine CX3CL1 and its receptor CX3CR1 play an important role in intercellular crosstalk between microglia and neurons,so the CX3CL1-CX3CR1 axis may become a new target for various neurodegenerative diseases,mental disorders and other pathological brain states.Here,we review the recent studies on the role of CX3CL1-CX3CR1 signaling axis in microglia’s crosstalk with neurons.

关 键 词：CX3CL1 CX3CR1 小胶质细胞 神经元 

分 类 号：R392[医药卫生—免疫学]