中药穴位敷贴联合西药治疗女性盆腔炎效果的Meta分析  

Effect of traditional Chinese medicine acupoint application therapy combined with Western medicine in the treatment of female pelvic inflammatory disease:a Meta-analysis

作　　者：胡荣湫 田甜 胡柯琴 王益平 HU Rongqiu;TIAN Tian;HU Keqin;WANG Yiping(Southwest Medical University,Sichuan 646000 China)

机构地区：[1]西南医科大学,四川646000 [2]西南医科大学附属中医医院

出　　处：《循证护理》2023年第4期594-600,共7页Chinese Evidence-Based Nursing

基　　金：四川省护理科研课题,编号:H18009;四川医院管理和发展研究中心项目,编号:SCYG2019-24。

摘　　要：目的:系统评价中药穴位贴敷联合西药治疗女性盆腔炎的有效性和安全性。方法:计算机检索PubMed、EMbase、the Cochrane Library、Web of Science、中国知网、万方数据库、中国生物医学文献数据库(CBM)和维普数据库,搜集有关中药穴位敷贴治疗女性盆腔炎有效性和安全性的随机对照试验(RCTs),检索时限均从建库至2022年3月1日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件和Stata 16.0软件进行Meta分析。结果:经筛选后最终纳入24个RCT,共2 132例病人。分析结果显示,中药穴位敷贴可提高临床疗效[RR=1.22,95%CI(1.15,1.29),P<0.000 01],改善中医证候积分[MD=-7.67,95%CI(-11.73,-3.61),P=0.000 2],中药穴位贴敷可以有效降低女性盆腔炎复发率[RR=0.26,95%CI(0.17,0.41),P<0.000 01],但在减轻不良反应方面,差异无统计学意义[RR=0.44,95%CI(0.06,3.01),P=0.40]。结论:现有证据表明,中药穴位贴敷配合西药对女性盆腔炎具有良好的治疗效果,但仍需要使用设计严谨且符合循证医学规范的大样本临床试验来提升现有的证据质量。Objective:To systematically evaluate the effectiveness and safety of acupoint application of traditional Chinese medicine combined with western medicine in the treatment of female pelvic inflammatory disease(PID).Methods:Randomized controlled trials on the efficacy and safety of acupoint application of traditional Chinese medicine in the treatment of PID were searched from PubMed,EMbase,the Cochrane Library,Web of Science,CNKI,WanFang Database,CBM and VIP.The retrieval time was from inception to March 1,2022.Two researchers independently screened literatures,extracted data,and evaluated the risk of bias in the included studies.Meta-analysis was performed using RevMan 5.4 software and Stata 16.0 software.Results:After screening,24 RCTs were finally included involoing,a total of 2132 patients.The analysis results showed that,acupoint application of traditional Chinese medicine could improve clinical efficacy[RR=1.22,95%CI(1.15,1.29),P<0.00001],improve TCM syndrome score[MD=-7.67,95%CI(-11.73,-3.61),P=0.0002],effectively reduce the recurrence rate of female PID[RR=0.26,95%CI(0.17,0.41),P<0.00001],but there was no significant difference in reducing adverse reactions[RR=0.44,95%CI(0.06,3.01),P=0.40].Conclusions:Current evidence shows that acupoint application of traditional Chinese medicine combined with western medicine has a good therapeutic effect on female PID.However,large sample clinical trials with rigorous design and in line with evidence-based medicine norms are still needed to improve the quality of existing evidence.

关 键 词：穴位贴敷 中西医结合 盆腔炎性疾病 随机对照试验 META分析 

分 类 号：R711.33[医药卫生—妇产科学]