血管紧张素Ⅱ1型受体A1166C基因多态性与中国人原发性高血压相关性的Meta分析  

作　　者：朱倩寅 沐婷玉 陈灵杉 沈翠珍[1] 

机构地区：[1]浙江中医药大学护理学院,310053

出　　处：《浙江临床医学》2023年第1期50-54,共5页Zhejiang Clinical Medical Journal

基　　金：浙江省中医药科技计划项目(2022ZA053)。

摘　　要：目的探讨血管紧张素Ⅱ1型受体(AT1R)A1166C基因多态性与中国人原发性高血压的相关性。方法系统检索PubMed、Web of science、Embase、Cochrane Library、中国知网(CNKI)、万方数据库、中国生物医学文献数据库(SinoMed)中关于AT1R A1166C基因多态性与中国人原发性高血压相关性的文献。两名研究者按照纳入与排除标准独立筛选文献、提取资料并进行文献质量评价后,采用RevMan 5.3软件进行Meta分析。结果最终纳入39篇文献,其中病例组12,638例,对照组8,494例。Meta分析结果显示AT1R A1166C的C等位基因(OR:1.80,95%CI:1.51~2.15,P<0.0001)和AC/CC基因型(OR:1.81,95%CI:1.49~2.20,P<0.0001)可增加患高血压的风险。通过亚组分析发现,在汉族、彝族人群和东部、中部人群中,C等位基因、AC/CC基因型增加原发性高血压的易感性,在西部人群中只有AC/CC基因型展现这种相关性,而年龄可能不是影响A1166C与高血压相关性的因素。结论AT1R A1166C基因的C等位基因和AC/CC基因型与中国人高血压易感性相关。Objective To analysis the association between angiotensinⅡtype 1 receptor(AT1R)A1166C gene polymorphism and the risk of essential hypertension among Chinese.Methods Searches were performed across PubMed,Web of science,Embase,Cochrane Library,CNKI,Wangfang database,SinoMed.Case-control studies that discussed the association of AT 1R A1166C gene polymorphism and essential hypertension among Chinese were included.All eligible studies were screened according to inclusion and exclusion criteria and examined.After screening and quality examining by two researchers independently,Meta-analysis were conducted using RevMan 5.3 software.Results 39 case-control studies involving 12,638 cases and 8,494 controls were included.The Meta-analysis showed that C allele(OR:1.80,95%CI:1.51~2.15,P<0.0001)and AC/CC genotype of AT1R A1166C(OR:1.81,95%CI:1.49~2.20,P<0.0001)might increase the risk of essential hypertension.In subgroup analysis,increased risk of essential hypertension was found in C allele,AC/CC genotype of Han and Yi,eastern and central subgroups.In western subgroup,only AC/CC genotype showed this correlation.Age might not obviously influence the relationship between A1166C polymorphism and essential hypertension.Conclusion A 1166C polymorphism in the AT1R gene is associated with the risk of essential hypertension in Chinese populations.

关 键 词：血管紧张素Ⅱ1型受体 高血压 基因多态性 META分析 

分 类 号：R54[医药卫生—心血管疾病]