可生物降解的聚氨酯体内应用进展  

Progress in the Application of Biodegradable Polyurethane In Vivo

作　　者：曹银利 傅锴锴 陈文 郑柳春 梅其勇 Cao Yinli;Fu Kaikai;Chen Wen(School of Medicine,Shanghai University,Shanghai 200444,China;Department of Neurosurgery,Second Affiliated Hospitalof Naval Medical University,Shanghai 200003,China)

机构地区：[1]上海大学医学院,上海200444 [2]海军军医大学第二附属医院神经外科,上海200003 [3]天津工业大学纺织科学与工程学院,天津300387

出　　处：《华中科技大学学报（医学版）》2023年第1期111-116,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81971711)。

摘　　要：聚氨酯由于其特殊的结构与性能,已被广泛应用于建筑、汽车、家居、医药等日常生活的诸多领域。因具有良好的生物相容性,聚氨酯材料在医药领域也极具应用前景。此外,通过对聚氨酯的分子结构进行设计,可以赋予其广泛的性能,如生物相容性、抗凝血特性、抗菌性能等。具有了这些特性的聚氨酯材料在组织工程、药物缓释等生物医药领域中被广泛应用。该文主要探讨了可生物降解聚氨酯在骨组织工程领域、血管组织工程领域、神经支架、药物缓释、人造皮肤和手术缝合线等医学方面的应用,并总结分析了其研究中存在的关键问题,展望了其未来的发展方向。Polyurethane has been widely used in many fields of daily life,such as construction,automobile,household supplies,medicine and so on,because of its special structure and properties.Due to its biocompatibility,polyurethane material is also highly promising for application in the field of medicine.In addition,by designing the molecular structure of polyurethane,it can be endowed with a wide range of properties,such as biocompatibility,anticoagulant properties,antibacterial properties and so on.Polyurethane material with these properties is widely used in biomedical fields such as tissue engineering and drug sustained release.This paper mainly discusses the applications of biodegradable polyurethanes in the fields of bone tissue engineering,vascular tissue engineering,nerve scaffold,drug sustained release,artificial skin and surgical sutures.The key problems in research are summarized and analyzed,and its future development direction is forecasted.

关 键 词：聚氨酯 生物降解 组织工程领域 神经支架 药物缓释 

分 类 号：R318.08[医药卫生—生物医学工程]