lncRNA-miRNA-mRNA轴在脓毒症炎症免疫机制中的研究进展  

Research Progress of lncRNA-miRNA-mRNA Axis in Inflammatory Immunity of Sepsis

作　　者：钱镭元 修光辉 孙洁[1] 凌斌 Qian Leiyuan;Xiu Guanghui;Sun Jie(Department of Critical Medicine,Affiliated Hospital of Yunnan University,Kunming 650021,China)

机构地区：[1]云南大学附属医院(云南省第二人民医院)重症医学科,昆明650021

出　　处：《华中科技大学学报（医学版）》2023年第1期117-122,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金青年基金项目(No.81901950);云南省应用基础研究计划面上项目(No.2019FB099);云南省科技厅-昆明医科大学联合专项资金项目(No.202001AY070001-166,No.2019FE001-009);云南省卫生计生高层次人才培养计划(No.H-2017060);云南省内分泌与代谢性疾病临床医学中心开放课题(No.202005AF150050)。

摘　　要：脓毒症是由宿主对感染的反应失调引起的危及生命的器官功能障碍,lncRNAs是转录长度超过200 nt但缺乏蛋白质编码能力的RNA分子,miRNA是一种在物种中高度保守的非编码RNA。lncRNA与miRNA、mRNA存在相互调节关系,形成了lncRNA-miRNA-mRNA相互调控网络。该网络主要通过“ceRNA”机制,参与了脓毒症的炎症反应及免疫信号通路的调控,并在其中发挥了重要功能。该文总结了lncRNA-miRNA-mRNA轴在炎症反应调控、重要免疫细胞调控中的研究,探讨lncRNA-miRNA-mRNA在炎症进展、免疫反应中的重要作用,为临床脓毒症诊治提供新的思路。Sepsis is a kind of life-threatening organ dysfunction caused by the host’s maladjusted response to infection.lncRNAs are RNA molecules whose transcription length exceed 200 nt yet lack protein coding ability.miRNA is a highly conserved non-coding RNA.There is a mutual regulatory relationship between lncRNA,miRNA and mRNA,forming a lncRNA-miRNA-mRNA regulatory network.This network plays an important role in the regulation of inflammatory response and immune signaling pathway in sepsis through“ceRNA”mechanism.This paper summarizes the studies on the lncRNA-miRNA-mRNA axis in the regulation of inflammatory response and the regulation of important immune cells,and explores the important role of lncRNA-miRNA-mRNA axis in the inflammatory progression and immune response,providing new ideas for the diagnosis and treatment of clinical sepsis.

关 键 词：lncRNA MIRNA ceRNA 脓毒症 炎症反应 免疫反应 

分 类 号：R631[医药卫生—外科学]