功能磁共振成像预测较低级别脑胶质瘤分子分型的研究进展  

Research progress in predicting molecular typing of lower grade glioma by functional magnetic resonance imaging

作　　者：申棚鑫 谭艳[2] SHEN Pengxin;TAN Yan(College of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China;Department of Radiology,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学医学影像学院,太原030001 [2]山西医科大学第一医院影像科,太原030001

出　　处：《磁共振成像》2023年第2期168-173,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:82071893)。

摘　　要：脑胶质瘤是颅内最常见的恶性肿瘤,复发率高,预后较差。较低级别脑胶质瘤是指2021世界卫生组织中枢神经系统肿瘤分类(World Health Organization Central Nervous System,WHO CNS)分级为2级和3级的肿瘤,较低级别脑胶质瘤的分子分型对其治疗与预后有着重要的指导意义,因此分子分型诊断对脑胶质瘤的临床管理至关重要。分子分型诊断的金标准是病理检测,获取病理组织基因测序,但其有一定的有创性和滞后性。近年来,随着功能磁共振成像(functional MRI,fMRI)的发展,越来越多的研究明确了fMRI预测较低级别胶质瘤分子分型的价值,本文就近年来多种fMRI技术,包括扩散成像、灌注成像、酰胺质子转移成像等,对预测较低级别胶质瘤多种分子分型的研究进展作一综述,并就各种fMRI技术对不同分子分型的预测价值分别进行分析,旨在为预测较低级别胶质瘤分子分型提供影像学指标,从而达到临床精准诊治的目的。Glioma is the most common intracranial malignant tumor with high recurrence rate and poor prognosis.Lower grade glioma refers to tumors classified into grade 2 and grade 3 by World Health Organization(WHO).Molecular classification of lower grade glioma has important guiding significance for its treatment and prognosis.Therefore,the diagnosis of molecular classification is of great important for clinical management of glioma.The genetic testing based on pathological tissue is the gold standard,which has certain invasiveness and hysteresis quality.In recent years,with the development of functional magnetic resonance imaging,more and more studies have clarified the value of functional magnetic resonance imaging in predicting molecular typing for lower grade glioma.This paper reviews the research progress of functional magnetic resonance imaging in predicting the molecular classification of lower grade gliomas in recent years.

关 键 词：较低级别脑胶质瘤 分子分型 磁共振成像 功能磁共振成像 扩散张量成像 扩散峰度成像 体素内不相干运动 平均表观传播因子磁共振成像 动脉自旋标记 动态磁敏感对比 动态对比增强 酰胺质子转移成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.264[医药卫生—诊断学]