中药干预卒中相关性肺炎合并多重耐药菌感染的回顾性研究  

A Retrospective Study of Traditional Chinese Medicine Intervention for Stroke-associated Pneumonia Combined with Multidrug Resistance Bacterial Infection

作　　者：杨霖轩 吴林纳 杨雪 么美康[1,2] 牛博真 尹丽丽[1] Yang Linxuan;Wu Linna;Yang Xue;Yao Meikang;Niu Bozhen;Yin Lili(The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300380,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300380 [2]天津中医药大学,天津301617

出　　处：《中国中医急症》2023年第2期212-216,共5页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81704136)。

摘　　要：目的观察中药对卒中相关性肺炎(SAP)合并多重耐药菌(MDRB)感染的疗效。方法回顾性收集127例于2016年1月至2021年6月期间首次诊断为SAP合并MDRB感染患者的临床资料,以连续接受中药汤剂且疗程不低于80%住院时间作为暴露因素分组,比较两组患者临床治愈率、微生物清除率、1年内肺炎相关死亡率的差异,并采用Logistic回归分析筛选出影响临床治愈的独立影响因素。结果暴露组临床治愈率(76.67%)高于非暴露组(56.76%),差异有统计学意义(P<0.05);暴露组1年内肺炎相关死亡率(42.22%)低于非暴露组(67.57%),差异有统计学意义(P<0.05);两组微生物清除率差异无统计学意义(P>0.05)。多因素Logistic回归分析结果显示:年龄、性别、临床肺部感染评分(CPIS)、是否使用中药是临床治愈的独立影响因素(P<0.05)。结论中药干预有利于改善SAP合并MDRB感染临床疗效,降低死亡率。Objective:To observe the efficacy of traditional Chinese medicine on stroke-associated pneumonia(SAP)combined with multidrug resistance bacteria(MDRB)infection.Methods:Clinical data were retrospectively collected from patients first diagnosed with SAP combined with MDRB infections between January 2016 and June 2021.Patients who received traditional Chinese medicine treatment with more than 80%of hospital stay were included in the exposed group,and the others were included in the non-exposed group.The differences in clinical cure rate,microbial clearance rate,and pneumonia-related mortality within 1 year between the two groups were compared.Logistic regression analysis was also used to screen out the independent influencing factors affecting clinical cure.Results:The clinical cure rate was higher in the exposed group(76.67%)than in the non-exposed group(56.76%)(P<0.05).Pneumonia-related mortality within 1 year was lower in the exposed group(42.22%)than in the non-exposed group(67.57%)(P<0.05).The difference in microbial clearance rates between the two groups was not statistically significant(P>0.05).The results of multi-factor logistic regression analysis showed that age,gender,clinical pulmonary infection score(CPIS),and whether or not to use traditional Chinese medicine were independent influencing factors for clinical cure(P<0.05).Conclusion:Traditional Chinese medicine interventions are beneficial in improving clinical outcomes and reducing mortality in SAP combined with MDRB infection.

关 键 词：卒中相关性肺炎 多重耐药菌 中药 回顾性研究 

分 类 号：R563.1[医药卫生—呼吸系统] R743.9[医药卫生—内科学]