阴阳周天隔药红外灸治疗强直性脊柱炎疗效及对炎性因子表达的影响  

Therapeutic Effect of Yin-Yang Zhoutian Medicinal Cake-Separated Infrared Moxibustion in Treating AS and Its Influence to Expressions of Inflammatory Factors

作　　者：程洁 张玉飞 谷雨[1] 毛丹 田元生 CHENG Jie;ZHANG Yufei;GU Yu;MAO Dan;TIAN Yuansheng(Henan University of Chinese Medicine,Zhengzhou 450000,China;Affiliated Hospital of Henan Academy of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,河南郑州450000 [2]河南中医药研究院附属医院,河南郑州450000

出　　处：《针灸临床杂志》2023年第1期44-48,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：河南省科技攻关项目,编号:162102310371;河南省中医药科学研究专项课题,编号:2018ZY1020。

摘　　要：目的:观察阴阳周天隔药红外灸对强直性脊柱炎(AS)的临床疗效及对炎性因子的影响。方法:选择88例患有肾阳亏虚型强直性脊柱炎的患者,以随机数字表法随机分为治疗组和对照组,各44例。对照组予西药治疗,观察组在对照组治疗的基础上给予阴阳周天隔药红外灸。两组疗程均为8周。观察并比较两组患者治疗前后AS活动指数(BASDAI)评分、AS功能指数(BASFI)评分、胸廓活动度、枕墙距、指地距、中医症状积分及炎症相关指标[血沉(ESR)、C反应蛋白(CRP)、肿瘤坏死因子(TNF)-α及基质金属蛋白酶3(MMP-3)]水平变化情况,并评估临床疗效。结果:治疗后两组患者BASDI评分、BASFI评分和症状积分均较治疗前明显降低,差异具有统计学意义(P<0.05),观察组中上述评分与对照组比较,差异具有统计学意义(P<0.05)。治疗后两组患者ESR、CRP、TNF-α及MMP-3(基质金属蛋白酶3)水平均较治疗前明显降低,观察组明显低于对照组,差异具有统计学意义(P<0.05)。观察组总有效率为93.18%(41/44),明显高于对照组的81.82%(36/44)。结论:阴阳周天隔药红外灸联合西药可以显著降低肾阳亏虚型AS患者的疾病活动度、缓解临床症状、减轻炎症反应和提高临床疗效。Objective:To observe the clinical effect of Yin-Yang Zhoutian medicinal cake-separated infrared moxibustion in treatment of ankylosing spondylitis(AS)and its influence to inflammatory factors.Methods:88 patients with AS of Kidney-Yang deficiency were randomly divided into the treatment group and the control group,with 44 cases in each group.The control group was treated with western medication;on which basis,the observation group was also treated with Yin-Yang Zhoutian medicinal cake-separated infrared moxibustion.The two groups was treated for 8 weeks.BASDAI score,BASFI score,thoracic activity,occipitalia-to-wall distance,finger-to-ground distance,TCM symptom scores and inflammation-related indicators,including ESR,CRP,TNF-αand MMP-3,were compared between before and after the treatment in the two groups.The clinical efficacy was compared between the two groups.Results:BASDI score,BASFI score,and TCM symptom score were significantly lower after the treatment than those before the treatment in the two groups(P<0.05);the scores in the treatment group were significantly lower in the observation group than those in the control group during the same period(P<0.05).The levels of ESR,CRP,TNF-α,and MMP-3 were significantly lower after the treatment than those before the treatment(P<0.05);the levels were significantly lower in the observation group than those in the control group(P<0.05).The total effective rate was 93.18%(41/44)in the observation group,which was significantly higher than 81.82%(36/44)in the control group(P<0.05).Conclusion:Yin-Yang Zhoutian medicinal cake-separated infrared moxibustion combined with western medication can significantly reduce the disease activity of AS with Kidney-Yang deficiency,relieve clinical symptoms,reduce inflammation and improve clinical efficacy.

关 键 词：强直性脊柱炎 肾阳亏虚 阴阳周天隔药红外灸 炎性因子 

分 类 号：R246.2[医药卫生—针灸推拿学]