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作 者:程洁 张玉飞 谷雨[1] 毛丹 田元生 CHENG Jie;ZHANG Yufei;GU Yu;MAO Dan;TIAN Yuansheng(Henan University of Chinese Medicine,Zhengzhou 450000,China;Affiliated Hospital of Henan Academy of Traditional Chinese Medicine,Zhengzhou 450000,China)
机构地区:[1]河南中医药大学,河南郑州450000 [2]河南中医药研究院附属医院,河南郑州450000
出 处:《针灸临床杂志》2023年第1期44-48,共5页Journal of Clinical Acupuncture and Moxibustion
基 金:河南省科技攻关项目,编号:162102310371;河南省中医药科学研究专项课题,编号:2018ZY1020。
摘 要:目的:观察阴阳周天隔药红外灸对强直性脊柱炎(AS)的临床疗效及对炎性因子的影响。方法:选择88例患有肾阳亏虚型强直性脊柱炎的患者,以随机数字表法随机分为治疗组和对照组,各44例。对照组予西药治疗,观察组在对照组治疗的基础上给予阴阳周天隔药红外灸。两组疗程均为8周。观察并比较两组患者治疗前后AS活动指数(BASDAI)评分、AS功能指数(BASFI)评分、胸廓活动度、枕墙距、指地距、中医症状积分及炎症相关指标[血沉(ESR)、C反应蛋白(CRP)、肿瘤坏死因子(TNF)-α及基质金属蛋白酶3(MMP-3)]水平变化情况,并评估临床疗效。结果:治疗后两组患者BASDI评分、BASFI评分和症状积分均较治疗前明显降低,差异具有统计学意义(P<0.05),观察组中上述评分与对照组比较,差异具有统计学意义(P<0.05)。治疗后两组患者ESR、CRP、TNF-α及MMP-3(基质金属蛋白酶3)水平均较治疗前明显降低,观察组明显低于对照组,差异具有统计学意义(P<0.05)。观察组总有效率为93.18%(41/44),明显高于对照组的81.82%(36/44)。结论:阴阳周天隔药红外灸联合西药可以显著降低肾阳亏虚型AS患者的疾病活动度、缓解临床症状、减轻炎症反应和提高临床疗效。Objective:To observe the clinical effect of Yin-Yang Zhoutian medicinal cake-separated infrared moxibustion in treatment of ankylosing spondylitis(AS)and its influence to inflammatory factors.Methods:88 patients with AS of Kidney-Yang deficiency were randomly divided into the treatment group and the control group,with 44 cases in each group.The control group was treated with western medication;on which basis,the observation group was also treated with Yin-Yang Zhoutian medicinal cake-separated infrared moxibustion.The two groups was treated for 8 weeks.BASDAI score,BASFI score,thoracic activity,occipitalia-to-wall distance,finger-to-ground distance,TCM symptom scores and inflammation-related indicators,including ESR,CRP,TNF-αand MMP-3,were compared between before and after the treatment in the two groups.The clinical efficacy was compared between the two groups.Results:BASDI score,BASFI score,and TCM symptom score were significantly lower after the treatment than those before the treatment in the two groups(P<0.05);the scores in the treatment group were significantly lower in the observation group than those in the control group during the same period(P<0.05).The levels of ESR,CRP,TNF-α,and MMP-3 were significantly lower after the treatment than those before the treatment(P<0.05);the levels were significantly lower in the observation group than those in the control group(P<0.05).The total effective rate was 93.18%(41/44)in the observation group,which was significantly higher than 81.82%(36/44)in the control group(P<0.05).Conclusion:Yin-Yang Zhoutian medicinal cake-separated infrared moxibustion combined with western medication can significantly reduce the disease activity of AS with Kidney-Yang deficiency,relieve clinical symptoms,reduce inflammation and improve clinical efficacy.
关 键 词:强直性脊柱炎 肾阳亏虚 阴阳周天隔药红外灸 炎性因子
分 类 号:R246.2[医药卫生—针灸推拿学]
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