Synthesis of dimeric butenolide catalyzed by various inorganic silver catalysts  

作　　者：Ruo-Meng Wei Qian-Qian Liu Ying Li Wen-Jiao Yan Xiao-Ru Zhang Ai-Qin Liu 

机构地区：[1]School of Pharmacy and Pharmaceutical Sciences,Shandong First Medical University,Jinan 250117,China [2]Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250117,China [3]NHC Key Laboratory of Biotechnology Drugs(Shandong Academy of Medical Sciences),Jinan 250117,China [4]Key Lab for Rare&Uncommon Diseases of Shandong Province,Jinan 250117,China [5]Department of Neurology,Liaocheng Third People’s Hospital,Liaocheng 252000,China

出　　处：《Traditional Medicine Research》2023年第6期33-38,共6页TMR传统医学研究

基　　金：Project supported by the Natural Science Foundation of Shandong Province(No.ZR2021MB102).

摘　　要：This article describes a method for synthesizing butyrolactone dimers using various inorganic silver salt catalysts.The method was successfully applied to alkyl 2-(2-bromopropyl)malonate 1,providing the dimeric butyrolactone 2 when catalyzed by different silver salt catalysts.This synthesis method not only simplifies the original synthetic route,but also cleverly combines with natural product analogs,providing a strategy for the development of natural product polymer analogs in the future.

关 键 词：Mikania SESQUITERPENES DIMER TOXICOLOGY silver catalysis 

分 类 号：O62[理学—有机化学]