肠道菌群在运动防治非酒精性脂肪性肝病中的作用机制研究进展  

Research Progress of the Mechanism of Gut Microbiota in the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease by Exercise

作　　者：刘洪武 戈莎[1] 廖粤生 Liu Hongwu;Ge Sha;Liao Yuesheng(College of Sports Science,Tianjin Normal University,Tianjin 300387,China;不详)

机构地区：[1]天津师范大学体育科学学院,天津300387 [2]江西科技学院体育学院,江西南昌330098

出　　处：《体育科技文献通报》2023年第1期242-246,共5页Bulletin of Sport Science & Technology

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是一种以慢性肝脏损伤为主要特征的代谢性疾病,是全球最为常见的慢性肝病之一。流行病学调查显示,NAFLD在世界范围内的患病率为6%~35%,且呈逐年上升趋势,给我国医药卫生系统及居民身心健康带来了严重的负担。NAFLD的发病机制复杂,其中肠道菌群失调就是诱导NAFLD发生与发展的重要原因。研究发现,运动作为治疗NAFLD的非药物手段,可能通过介导胆汁酸、丁酸盐和乙醇等肠道菌群代谢产物起到防治NAFLD的作用,但其中的具体作用机制尚不十分清楚。因此,本文通过查询中国知网、万方、Web of Science、PubMed、Medline和WHO等官网与数据库的文献,对肠道菌群与NAFLD的关系、运动对肠道菌群的影响及肠道菌群在运动防治NAFLD中的作用机制进行梳理,以期为NAFLD的临床治疗提供新的治疗靶点。Non-alcoholic fatty liver disease(NAFLD)is a metabolic disease characterised by chronic liver damage and one of the most common chronic liver diseases in the world. Epidemiological surveys show that the prevalence of NAFLD ranges from 6% to 35% worldwide and is increasing year by year, posing a heavy burden on the medical and health systems and the physical and mental health of the population in China. The pathogenesis of NAFLD is complex, among which the imbalance of gut microbiota is an important cause inducing the occurrence and development of NAFLD. It has been disclosed that exercise, as a non-pharmacological treatment of NAFLD, may play a role in the prevention and treatment of NAFLD by mediating the metabolites of gut microbiota such as bile acids, butyrate and ethanol, but the exact mechanism of action is yet to be well understood. Therefore, this study compares and analyses the relationship between gut microbiota and NAFLD, the effect of exercise on gut microbiota and the mechanism of action of gut microbiota in the prevention and treatment of NAFLD through the official websites and databases of China Knowledge Network, Wanfang, Web of Science, PubMed, Medline and WHO, in an effort to provide new therapeutic targets for the clinical treatment of NAFLD.

关 键 词：肠道菌群 非酒精性脂肪性肝病 运动防治脂肪肝 

分 类 号：G804.7[文化科学—运动人体科学]