层粘连蛋白α4亚基的功能及其与疾病关系的研究进展  

Research Progress on the Role of Laminin Subunit Alpha 4 in Diseases

作　　者：于晶晶 张丽君 何春草 曹亦菲[1] 杨军[1,2] YU Jingjing;ZHANG Lijun;HE Chuncao;CAO Yifei;YANG Jun(Deparment of Preventive Medicine,School of Public Health,Hangzhou Normal University,Hangzhou 311121,China;Zhejiang Provincial Research Center for Uterine Cancer Diagnosis and Therapy,Women’s Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China)

机构地区：[1]杭州师范大学公共卫生学院预防医学系,杭州311121 [2]浙江大学附属妇产科医院浙江省子宫恶性肿瘤诊治研究中心,杭州310006

出　　处：《中国医学科学院学报》2023年第1期92-100,共9页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(31971138);浙江省自然科学基金(LZ19H260001);浙江省医药卫生科技计划项目(2022506699)。

摘　　要：层粘连蛋白家族是基底膜的主要成分。作为家族中的一员,层粘连蛋白α4亚基(LAMA4)广泛存在于成人组织的细胞间质中,参与细胞的固定,并可与相应的整合素受体结合,激活相关的信号转导通路,对于细胞的生长、增殖和迁移,以及人体的正常生长发育均起着重要作用。现有的研究已发现LAMA4与许多疾病的发生、发展有关;此外,还发现LAMA4与多种肿瘤细胞的迁移和侵袭有密切的联系。本文综述了当前LAMA4的研究进展,着重探讨LAMA4与疾病尤其是肿瘤发生发展的关系,以期为相关疾病的诊治提供新的思路。Laminin subunit alpha 4(LAMA4),a member of the laminin family,is present in the intercellular matrix of adult tissues as a major component of basement membrane.LAMA4 is involved in the adhesion of cells and can bind to corresponding integrins to activate relevant signaling pathways,playing an essential role in the growth,proliferation,and migration of cells.It has been demonstrated that LAMA4 is associated with the occurrence and development of a variety of diseases including tumors,and the expression of LAMA4 can be used as a biomarker of tumor diagnosis and prognosis.This paper summarizes the current research progress in LAMA4 with the focus on the relationship between LAMA4 and diseases,especially tumor,with a view to provide new directions for the future research.

关 键 词：层粘连蛋白 层粘连蛋白α4亚基 肿瘤 迁移 侵袭 

分 类 号：Q754[生物学—分子生物学]