大麻二酚在肿瘤治疗中的应用  

Cannabidiol in tumor therapy

作　　者：周锐奕 吴晓聪 雷毅[2] 孙加学 徐玉[1,2] 王昆华[1,3] Zhou Ruiyi;Wu Xiaocong;Lei Yi;Sun Jiaxue;Xu Yu;Wang Kunhua(NHC Key Laboratory of Drug Addiction Medicine,Kunming Medical University,Kunming 650032,Yunnan,China;Department of Gastrointestinal and Hernia Surgery,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan,China;Yunnan University,Kunming 650032,Yunnan,China)

机构地区：[1]国家卫生健康委毒品依赖和戒治重点实验室,昆明医科大学,昆明650032 [2]昆明医科大学第一附属医院胃肠与疝外科,昆明650032 [3]云南大学,昆明650032

出　　处：《肿瘤代谢与营养电子杂志》2023年第1期140-148,共9页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家自然科学基金项目(82060525);云南省云岭学者项目(YLXL20170002);云南省黄昌明专家工作站(202005AF150090)。

摘　　要：大麻二酚(CBD)是植物大麻提取物的主要成分。CBD是非精神活性物质,无成瘾性、毒性低、安全性高。因其具有良好的抗炎、抗氧化、神经保护等作用成为研究热点,已被用于治疗多种难治性癫痫。CBD在肿瘤治疗中展现独特优势,其机制有:(1)诱导细胞周期阻滞,抑制肿瘤细胞增殖;(2)增加肿瘤细胞活性氧家族水平、诱导线粒体功能紊乱、调控Bcl-2家族蛋白、抑制IAP家族蛋白功能等多种途径,促进肿瘤细胞凋亡;(3)抑制肿瘤细胞迁移和侵袭;(4)联合其他抗癌治疗发挥更强的抗肿瘤作用;(5)缓解诸如疼痛、焦虑、抑郁等肿瘤相关症状;(6)可能存在调节肿瘤微环境的作用。CBD在多种肿瘤治疗中展现出良好的抗肿瘤特性,有望作为一种新的肿瘤治疗药物投入临床使用。目前CBD与肿瘤治疗相关的临床试验主要聚焦于对晚期肿瘤患者的镇痛治疗,其直接治疗作用仍有待进一步临床试验。Cannabidiol( CBD) is the main component of cannabis extract, which is a non-psychoactive substance with nonaddictive, low toxicity and high safety. CBD has shown unique advantages in tumor therapy, and is being used on refractory epilepsy. Its mechanisms include as follows.(1) Inducing cell cycle arrest and inhibiting tumor cell proliferation.(2) Promoting tumor cell apoptosis through increasing ROS levels in tumor cells, inducing mitochondrial dysfunction, regulates Bcl-2 family proteins and inhibiting IAP family protein function.(3) Inhibiting tumor cell migration and invasion.(4) In conjunction with other anti-cancer therapies to exert a stronger anti-tumor effect.(5)Relieve tumor-related symptoms such as pain, anxiety and depression.(6)It may play a role in regulating the tumor microenvironment. CBD has shown good anti-tumor properties in various tumor treatments, and is expected to be used as a new tumor treatment drug in clinical practic. At present, clinical trials related to CBD and cancer treatment mainly focus on analgesic treatment for patients with advanced tumors, and its direct therapeutic effect still needs further clinical trials.

关 键 词：大麻二酚 肿瘤 治疗 

分 类 号：R285[医药卫生—中药学]