西格列汀治疗2型糖尿病合并急性脑梗死的疗效及其对患者睡眠质量的影响  

Effect of Sitagliptin on Type 2 Diabetes Mellitus Complicated with Acute Cerebral Infarction and Its Influence on Sleep Quality

作　　者：刘岳毅 李元宇 冯敬怀 罗旌跃 LIU Yueyi;LI Yuanyu;FENG Jinghuai;LUO Jingyue(Department of Neurology,Yong′an Municipal Hospital,Yong′an 366000,China)

机构地区：[1]永安市立医院神经内科,永安366000

出　　处：《世界睡眠医学杂志》2022年第12期2235-2237,2241,共4页World Journal of Sleep Medicine

摘　　要：目的:探析2型糖尿病(T2DM)合并急性脑梗死(ACI)共病患者应用西格列汀治疗的疗效。方法:选取2021年1月至2022年6月永安市立医院收治的T2DM合并ACI患者86例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组43例。2组均给予标准治疗,对照组联合格列美脲片治疗,观察组联合西格列汀治疗,2组均连续治疗1个月。比较2组患者临床疗效、美国国立卫生研究院卒中量表(NHISS)评分、糖化血红蛋白(HbA1c)水平、血清生物学标志物[同型半胱氨酸(Hcy)、胱抑素C(CysC)、血管内皮生长因子(VEGF)、脂蛋白相关磷脂酶A2(Lp-PLA2)]、药品不良反应(ADR)发生率及匹兹堡睡眠质量指数(PSQI)评分。结果:观察组患者治疗有效率为95.35%,对照组为79.07%,2组比较差异有统计学意义(P<0.05)。治疗后,观察组NHISS评分、HbA1c水平、Hcy水平、CysC水平、VEGF及Lp-PLA2水平明显低于对照组,2组比较差异均有统计学意义(均P<0.05)。2组药品不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组PSQI评分低于对照组,2组比较差异有统计学意义(P<0.05)。结论:西格列汀治疗T2DM合并ACI效果显著,可有效降低患者神经缺损评分,提高血糖控制水平,改善相关血清学指标,提升睡眠质量,值得临床推广应用。Objective:To explore the therapeutic effect of sigliptin on comorbidity of type 2 diabetes mellitus(T2DM)with acute cerebral infarction(ACI).Methods:A total of 86 patients with T2DM and ACI who were hospitalized in Yong′an Municipal Hospital from January 2021 to June 2022 were selected and randomly divided into control group and observation group,with 43 patients in each group.Both groups were given standard treatment.The control group was treated with glimepiride tablets,and the observation group was treated with sitagliptin.Both groups were treated continuously for 1 month.The disease improvement effect,National Institute of Health Stroke Scale(NHISS)score,glycosylated hemoglobin(HbA1c)level,serum biomarkers such as homocysteine(Hcy),cystatin C(CysC),vascular endothelial growth factor(VEGF)and lipoprotein associated phospholipase A2(Lp PLA2),adverse drug reactions(ADR)and Pittsburgh Sleep Quality Index(PSQI)were compared between the two groups.Results:The improvement rate of comorbid patients in the observation group(95.35%)was significantly higher than that in the control group(79.07%)(P<0.05).After treatment,the scores of NHISS,HbA1c,Hcy,CysC,VEGF and Lp PLA2 in the observation group were significantly lower than those in the control group(P s<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).After treatment,the PSQI score of the observation group was lower than that of the control group(P<0.05).Conclusion:Sigliptin has a significant effect in the treatment of T2DM with ACI,which can effectively reduce the score of nerve defect,improve the level of blood glucose control,improve the prognosis related serological indicators,and improve the quality of sleep,which is worthy of clinical promotion.

关 键 词：2型糖尿病 急性脑梗死 西格列汀 临床疗效 

分 类 号：R587.1[医药卫生—内分泌] R473.3[医药卫生—内科学]