强化胰岛素结合二甲双胍治疗糖尿病合并颅脑外伤对HOMA-IR及空腹胰岛素指标及睡眠质量的影响  

Effects of Intensive Insulin Combined with Metformin on HOMA-IR,Fasting Insulin and Sleep Quality in Patients with Diabetes Complicated with Craniocerebral Injury

作　　者：石磊 潘智丰 罗旌跃 魏祥皇 SHI Lei;PAN Zhifeng;LUO Jingyue;WEI Xianghuang(Neurosurgery Department,Yong′an Municipal Hospital,Yong′an 366000,China)

机构地区：[1]永安市立医院神经外科,永安366000

出　　处：《世界睡眠医学杂志》2022年第12期2273-2275,共3页World Journal of Sleep Medicine

摘　　要：目的:分析强化胰岛素联合二甲双胍治疗糖尿病合并颅脑外伤对空腹胰岛素(FIns)、胰岛素抵抗水平(HOMA-IR)指标及睡眠质量的影响。方法:选取2021年3月至2022年3月永安市立医院收治的糖尿病合并颅脑外伤患者80例作为研究对象,按照入院先后顺序分为对照组和观察组,每组40例。对照组给予胰岛素治疗,观察组实施强化胰岛素结合二甲双胍治疗,比较2组患者治疗后的HOMA-IR、FIns水平、胰岛素使用时间、感染发生率、血糖水平及睡眠质量。结果:治疗前,2组患者FIns、HOMA-IR和血糖水平比较,差异均无统计学意义(均P>0.05);治疗后,2组患者FIns、HOMA-IR水平均下降,观察组患者FIns、HOMA-IR水平低于对照组,观察组的血糖水平、感染发生率和胰岛素使用时间均低于对照组,2组比较差异均有统计学意义(均P<0.05)。治疗后,观察组患者匹兹堡睡眠质量指数(PSQI)评分显著低于对照组,2组比较差异有统计学意义(P<0.05)。结论:在糖尿病合并颅脑外伤患者中应用强化胰岛素联合二甲双胍治疗,可增强控制血糖的效果,降低并发症发生率,可明显改善胰岛素抵抗,稳定病情,且能够改善患者的睡眠质量,值得临床推广应用。Objective:To analyze the effects of intensive insulin combined with metformin on the indexes of fasting insulin(FIns),HOMA-IR and sleep quality in patients with diabetes complicated with craniocerebral injury.Methods:From March 2021 to March 2022 in Yong′an Municipal Hospital,80 patients with diabetes combined with craniocerebral injury were selected as the study subjects.According to the order of admission,they were divided into two groups,with 40 patients in each group.The control group was given insulin treatment,and the observation group was given intensive insulin combined with dimethylbiguanide.The insulin resistance(HOMA-IR),fasting insulin(FIns)indexes,insulin use time,infection rate,blood glucose level and sleep quality.Results:The indexes of FIns and HOMA-IR in the observation group decreased significantly and were lower than those in the control group.The blood glucose level,infection rate and insulin use time in the observation group were lower than those in the control group.There were statistically significant differences between the two groups(P s<0.05).There was no significant difference in the changes of FIns,HOMA-IR and blood glucose between the groups before treatment(P s>0.05).After treatment,the PSQI score of the observation group was significantly lower than that of the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion:Intensive insulin combined with metformin in the treatment of diabetes complicated with craniocerebral injury can strengthen the effect of blood glucose control,reduce complications,significantly improve insulin resistance,stabilize the condition,and improve the sleep quality of patients.It is recommended clinically.

关 键 词：强化胰岛素 二甲双胍 糖尿病 颅脑外伤 

分 类 号：R587.1[医药卫生—内分泌] R651.1[医药卫生—内科学]