MicroRNA调控抗病毒免疫和病毒复制  

MicroRNAs Regulate Antiviral Immunity and Viral Replication

作　　者：王岚 何明宇[1,2] 张敏 丁军涛 WANG Lan;HE Mingyu;ZHANG Min;DING Juntao(College of Life Science and Technology,Xinjiang University,Urumqi 830046,China;Xinjiang Key Laboratory of Biological Resources and Genetic Engineering,Urumqi 830046,China)

机构地区：[1]新疆大学生命科学与技术学院,乌鲁木齐830046 [2]新疆生物资源基因工程重点实验室,乌鲁木齐830046

出　　处：《畜牧兽医学报》2023年第2期463-472,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：新疆维吾尔自治区自然科学基金面上项目(2016D01C041)。

摘　　要：MicroRNA(miRNA)是一类高度保守的内源性非编码单链小RNA分子,长度约为19~25 nt,通常在基因表达的转录后水平起调控作用,参与细胞发育、增殖、凋亡、免疫等多种生命活动。大量的研究表明,多种miRNAs通过直接或间接的方法在病毒感染期间调节病毒复制、细胞增殖或凋亡以及肿瘤发育等生物反应。本文主要对病毒感染期间miRNA在免疫反应、病毒复制中的调控机制进行综述,旨在为miRNA的开发应用和抗病毒相关治疗策略提供参考。MicroRNA(miRNA) is a class of highly conserved endogenous non-coding single-stranded small RNA molecules, about 19~25 nt in length, which usually plays a regulatory role in the post-transcriptional level of gene expression and participates in a variety of life activities such as cell development, proliferation, apoptosis and immunity. A large number of studies have shown that a variety of miRNAs regulate viral replication, cell proliferation or apoptosis and tumor development during viral infection through direct or indirect methods. This paper mainly reviews the regulatory mechanism of miRNA in immune response and viral replication during viral infection, aiming to provide reference for the development and application of miRNA and antiviral related treatment strategies.

关 键 词：MICRORNA 病毒感染 病毒复制 免疫调控 

分 类 号：Q527.5[生物学—生物化学]