姜黄素调控肠道菌群及抗病毒作用研究进展  

Advances in the Roles of Curcumin on Regulating Gut Microbiota and Antiviral Effects

作　　者：卓儒浩 柳清扬 钟翔[1] ZHUO Ruhao;LIU Qingyang;ZHONG Xiang(College of Animal Science and Technology,Nanjing Agricultural University,Nanjing 210095,China;College of Life Science,Nanjing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学动物科技学院,南京210095 [2]南京农业大学生命科学学院,南京210095

出　　处：《畜牧兽医学报》2023年第2期473-483,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31872391);中央高校基本科研业务费专项资金资助(KYCXJC2022001)。

摘　　要：姜黄素作为一种天然的多酚类植物提取物,具有抗炎、抗氧化、抗应激和改善动物肠道健康等多种生物学功能,已成为一种绿色安全高效的饲料添加剂。近年研究表明,姜黄素与肠道菌群存在紧密的相互作用。姜黄素能调控肠道菌群的组成和多样性,肠道菌群则影响姜黄素的转化。这种双向调控作用或许是姜黄素发挥生理功能的关键。此外,姜黄素被证实通过不同的机制抵抗多种病毒的感染,提示其具有成为新型抗病毒药物的潜力。因此,本文主要综述了姜黄素与肠道菌群之间的相互作用及姜黄素抵抗不同病毒感染的相关机制,以期为深入了解姜黄素对改善动物健康的作用机制和开发新型绿色饲料添加剂提供理论依据。As a natural polyphenolic plant extract, curcumin has many biological activities such as anti-inflammatory, anti-oxidant, anti-stress and improving animal intestinal health, and has become a green, safe and efficient feed additive. In recent years, studies have shown that curcumin has a close interaction with the gut microbiota. Curcumin can regulate the composition and diversity of the gut microbiota, and the gut microbiota affects the conversion of curcumin. This two-way regulation may be very important to the physiological function of curcumin. In addition, curcumin has been confirmed to resist multiple viral infections through different mechanisms, suggesting that it has the potential to become a new type of antiviral drug. Therefore, this article mainly reviews the interaction between curcumin and the gut microbiota and the related mechanisms of curcumin against different viral infections, with the final aim of providing theoretical basis for further understanding the mechanism of curcumin on improving animal health, and developing novel environment-friendly feed additive.

关 键 词：姜黄素 肠道菌群 调控作用 抗病毒作用 

分 类 号：S816.7[农业科学—饲料科学]