姜黄素与肠道微生物间相互作用研究进展  

Research Progress on Interaction between Curcumin and Gut Microbiota

作　　者：陈鑫宇 潘士锋 邢华[1,2] 闫婕 CHEN Xinyu;PAN Shifeng;XING Hua;YAN Jie(College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses,Yangzhou 225009,China)

机构地区：[1]扬州大学兽医学院,扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,扬州225009

出　　处：《动物营养学报》2023年第2期782-788,共7页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(32072809,31501923);江苏省自然科学基金项目(BK20211119,BK20150443);扬州大学高端人才支持计划(拔尖人才)(2018年度)(No.137080146);江苏高校优势学科建设工程资助项目(PAPD);江苏省研究生科研与实践创新计划资助项目(KYCX21_3275,KYCX22_3549)。

摘　　要：姜黄素是近年来研究较为深入的植物源活性成分之一,具有抗炎、抗氧化、抗应激、抗肿瘤、抗病毒和降血糖血脂等多种药理学功能。目前,一系列研究数据表明,姜黄素可通过调节肠道菌群改善肠道屏障功能。此外,姜黄素还可经肠道菌群直接代谢或由宿主-肠道菌群相互作用产生生物活性代谢产物,从而进一步增强姜黄素对动物肠道健康的保护作用。姜黄素与肠道菌群之间的双向调节作用表明姜黄素在维持宿主肠道健康以及预防或治疗多种疾病方面具有巨大的应用潜力。本文综述了姜黄素与肠道菌群之间的相互作用及其在畜禽生产中的应用等最新研究进展,从而为将姜黄素作为一种新型饲料添加剂、以及潜在的“替抗”物质应用于畜禽生产中提供参考,有益于推动畜牧养殖业的健康发展。Curcumin is one of the plant-derived active ingredients that has been deeply studied in recent years,which has extensive pharmacological functions such as anti-inflammatory,antioxidant,antistress,antitumor,antiviral and lowering blood glucose and lipids.At present,numerous studies have demonstrated that curcumin can improve intestinal barriers by regulating the intestinal microbiota.In addition,curcumin can be directly metabolized through the gut microbiota or further generate metabolites with biological activity by the combined metabolism of host and gut microbiota,thereby enhancing the promotion of curcumin on animal intestinal health,indicating that the interaction between curcumin and gut microbiota is of great potential in maintaining the gut health of the host and prevention or treatment of multiple diseases.This paper summarized the latest research progress of the interactions between curcumin and gut microbiota and its application in livestock and poultry production,so as to provide references for the further study of the application of curcumin as a novel feed additive and a potential new antibiotic substitute in livestock and poultry production,which is conducive to promote the healthy development of livestock and poultry breeding.

关 键 词：姜黄素 肠道微生物群 相互调控作用 饲料添加剂 畜禽生产 

分 类 号：S816[农业科学—饲料科学]