补中益气汤对中晚期恶性肿瘤患者化疗后不良反应的影响  

The Influence of Center-Supplementing and Qi-Boosting Decoction on Adverse Reactions of Patients with Advanced Malignant Tumor After Chemotherapy

作　　者：热娜古丽·艾则孜[1] 付艳丽 何娜娜[1] 陆明[1] RENAGU LI Aizezi;FU Yan-li;HE Na-na;LU Ming(Hie Fourth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,China,830011;Shenzhc Hospital of Guangzhou University of Chinese Medicine(Futian),Shenzhen.Guangdong,China,518000)

机构地区：[1]新疆医科大学第四附属医院,新疆乌鲁木齐830011 [2]广州中医药大学深圳医院(福田),广东深圳518000

出　　处：《河南中医》2023年第2期238-241,共4页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81760860)。

摘　　要：目的:观察补中益气汤对中晚期恶性肿瘤患者化疗后不良反应的影响。方法:选取2019年4月至2021年6月新疆医科大学第四附属医院肿瘤一科接受化疗的中晚期恶性肿瘤患者120例,按照随机数字表法分为对照组和观察组,每组60例。对照组给予常规化疗治疗,观察组在对照组化疗的基础上加用补中益气汤治疗。观察两组患者治疗后呕吐发生率、骨髓抑制反应发生率及治疗前后健康状态、生存质量、中医证候积分和睡眠质量改善情况。结果:观察组呕吐发生率为8.33%,对照组呕吐发生率为25.00%,观察组低于对照组,差异有统计学意义(P<0.05);观察组骨髓抑制反应发生率为6.66%,对照组骨髓抑制反应发生率为21.66%,观察组低于对照组,差异有统计学意义(P<0.05);观察组补中益气汤治疗后各时段Karnofsky功能状态评分高于对照组,差异有统计学意义(P<0.05);观察组治疗后中医证候积分低于对照组,差异有统计学意义(P<0.05);观察组治疗后睡眠质量评分低于对照组,差异有统计学意义(P<0.05)。结论:补中益气汤治疗中晚期恶性肿瘤,可减少患者呕吐发生率,降低骨髓抑制反应,改善机体健康状态,提高患者生存质量。Objective: To observe the influence of Center-Supplementing and Qi-Boosting Decoction on adverse reactions of patients with advanced malignant tumor after chemotherapy.Methods: A total of 120 patients with advanced malignant tumors who received chemotherapy in the First Department of Cancer, the Fourth Affiliated Hospital of Xinjiang Medical University from April 2019 to June 2021were selected and divided into the control group and the observation group according to the random number table, with 60 cases in each group.The control group was treated with conventional chemotherapy, while the observation group was treated with Center-Supplementing and Qi-Boosting Decoction on the basis of chemotherapy in the control group.The incidences of vomiting and myelosuppression reaction, the improvement of health status, quality of life, TCM syndrome scores and sleep quality after treatment were observed.Results: The incidence of vomiting in the observation group was 8.33%,and that in the control group was 25.00%.The incidence of vomiting in the observation group was lower than that in the control group, with a statistically significant difference(P<0.05).The incidence of myelosuppression reaction in the observation group was 6.66%,while that in the control group was 21.66%.The incidence of myelosuppression reaction in the observation group was lower than that in the control group, with a statistically significant difference(P<0.05).After treatment, the Karnofsky functional status score of Center-Supplementing and Qi-Boosting Decoction in the observation group was higher than that of the control group at each period, with a statistically significant difference(P<0.05);The TCM syndrome scores of the observation group was lower than those of the control group, with statistically significant differences(P<0.05);The sleep quality score of the observation group was lower than that of the control group, with a statistically significant difference(P<0.05).Conclusion: Center-Supplementing and Qi-Boosting Decoction can reduce the inci

关 键 词：恶性肿瘤 中晚期 补中益气汤 化疗 不良反应 骨髓抑制 

分 类 号：R259[医药卫生—中西医结合]