扶阳活血方治疗气滞血瘀型不能进行血运重建的冠状动脉粥样硬化性心脏病临床研究  

Clinical Study on Decoction for Reinforcing Yang and Activating Blood Circulation in Failure to Construct Blood Circulation of Coronary Atherosclerotic Heart Disease with Qi Stagnation and Blood Stasis Syndrome

作　　者：林鹃[1] 郑梦丹[1] 琚杰 LIN Juan;ZHENG Meng-dan;JU Jie(Jiaozuo People's Hospital,Jiaozuo,Henan,China,454002)

机构地区：[1]焦作市人民医院,河南焦作454002

出　　处：《河南中医》2023年第2期262-266,共5页Henan Traditional Chinese Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20191347)。

摘　　要：目的:观察扶阳活血方治疗气滞血瘀型不能进行血运重建的冠状动脉粥样硬化性心脏病(Coronary atherosclerotic heart disease, CHD)的临床疗效。方法:将98例气滞血瘀型不能进行血运重建的CHD患者按照随机数表法分为研究组和对照组,每组各49例。对照组给予常规西医治疗,研究组在对照组治疗的基础上给予扶阳活血方治疗。比较两组患者的临床疗效及治疗前后中医证候积分、血液流变学指标以及血清生化指标[超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、同型半胱氨酸(Homocysteine, Hcy)、血管扩张刺激磷蛋白(Vasodilatory stimulating phosphoprotein, VASP)]及生活质量评分变化情况。结果:对照组有效率为77.55%,研究组有效率为93.88%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分低于本组治疗前,且治疗后研究组低于对照组,差异具有统计学意义(P<0.05)。两组患者血液流变学指标水平低于本组治疗前,且治疗后研究组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后hs-CRP、Hcy水平低于本组治疗前,VASP水平高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后生活质量评分低于本组治疗前,且治疗后研究组低于对照组,差异具有统计学意义(P<0.05)。结论:扶阳活血方治疗气滞血瘀型不能进行血运重建的CHD,可改善患者临床症状和血液流变学指标,减轻炎症状态,提高生活质量。Objective: To observe the clinical efficacy of Decoction for Reinforcing Yang and Activating Blood Circulation on patients failing to construct blood circulation of coronary atherosclerotic heart disease(CHD) with qi stagnation and blood stasis syndrome.Methods: According to the method of random number table, 98 patients with CHD syndrome of qi stagnation and blood stasis who could not carry out blood circulation reconstruction were divided into the study group and the control group, with 49 cases in each group.The control group was treated with conventional Western medicine, while the study group was treated with Decoction for Reinforcing Yang and Activating Blood Circulation on the basis of the control group.The clinical efficacy, the changes of TCM syndrome score, hemorheology index, serum biochemical index [including hypersensitive C-reactive protein(hs-CRP),homocysteine(Hcy),vasodilatory stimulating phosphoprotein(VASP)] and quality of life score before and after treatment of the two groups were compared.Results: The effective rate was 77.55% in the control group and 93.88% in the study group.The difference between the two groups was statistically significant(P<0.05).After treatment, the TCM syndrome score of the two groups was lower than that of the same group before treatment, and the study group′s was lower than that of the control group, and the difference was statistically significant(P<0.05).The level of hemorheology index in the two groups was lower than that of the same group before treatment, and the study group′s was lower than that of the control group after treatment, and the difference was statistically significant(P<0.05).The levels of hs-CRP and Hcy in the two groups were lower than those of the same group before treatment, while the level of VASP was higher than that of the same group before treatment, and all the differences between the two groups were statistically significant(P<0.05).The quality of life score of patients in the two groups after treatment was lower than that before trea

关 键 词：冠状动脉粥样硬化性心脏病 血运重建 气滞血瘀证 扶阳活血方 中西医结合疗法 

分 类 号：R259.414[医药卫生—中西医结合]