益肾通络方联合促性腺激素释放激素拮抗剂方案对卵巢储备功能低下患者妊娠结局的影响  

The Influence of Kidney-Boosting and Meridian-Dredging Decoction Combined with Gonadotropin Releasing Hormone Antagonist Scheme on Pregnancy Outcome in Patients with Low Ovarian Reserve Function

作　　者：赵艳晓[1] 赵雷[2] ZHAO Yan-xiao;ZHAO Lei(Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China,450008;The Affiliated Hospital of Henan Academy of Chinese Medicine,Zhengzhou,Henan,China,450003)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450008 [2]河南省中医药研究院附属医院,河南郑州450003

出　　处：《河南中医》2023年第2期272-275,共4页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82004406)。

摘　　要：目的:探讨益肾通络方联合促性腺激素释放激素拮抗剂方案对卵巢储备功能低下患者妊娠结局的影响。方法:将60例卵巢储备功能低下患者按照随机数字表法分为观察组和对照组,每组各30例。对照组接受促性腺激素释放激素拮抗剂治疗,观察组在对照组治疗的基础上加用益肾通络方。比较两组患者治疗前后中医证候积分、血清激素指标[黄体生成素(luteinizing hormone, LH)、卵泡刺激素(follicle-stimulating hormone, FSH)、雌二醇(estradiol, E2)]、子宫内膜容受性相关血流指标[卵巢间质动脉舒张末期流速(end diastolic velocity, EDV)、卵巢间质动脉收缩期峰值流速(peak systolic velocity, PSV)、阻力指数(resistance index, RI)、搏动指数(pulsatile index, PI)]变化情况及妊娠结局(卵裂率、优胚率、受精率、妊娠率)。结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后观察组治疗后各项中医证候积分均低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后FSH、LH低于本组治疗前,E2高于本组治疗前,观察组治疗后FSH、LH低于对照组,E2高于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后EDV、PSV检高于本组治疗前,RI、PI低于本组治疗前,观察组治疗后EDV、PSV高于对照组,RI、PI低于对照组,差异均有统计学意义(P<0.05)。观察组优胚率、受精率和妊娠率均高于对照组,差异具有统计学意义(P<0.05)。结论:益肾通络方联合促性腺激素释放激素拮抗剂方案能够有效改善卵巢储备功能低下患者激素水平和子宫内膜容受性,提高妊娠率。Objective: To explore into the influence of Kidney-Boosting and Meridian-Dredging Decoction combined with gonadotropin releasing hormone antagonist scheme on pregnancy outcome in patients with low ovarian reserve function.Methods: A total of 60 patients with low ovarian reserve function were randomly divided into the observation group and the control group, with 30 cases in each group.The control group was treated with gonadotropin releasing hormone antagonist, while the observation group was treated with Kidney-Boost and Meridian-Dredging Decoction on the basis of the control group.The changes of TCM syndrome scores, serum hormone indexes [including luteinizing hormone(LH),follicular stimulating hormone(FSH),estradiol(E2)],endometrial receptivity related blood flow indexes [including end diastolic velocity(EDV),peak systolic velocity(PSV),resistance index(RI),pulsatile index(PI)],and pregnancy outcomes(such as cleavage rate, excellent embryo rate, fertilization rate, pregnancy rate) were compared between the two groups before and after treatment.Results: The TCM syndrome scores of the two groups after treatment were lower than those of the group before treatment, and the TCM syndrome scores of the observation group after treatment were lower than those of the control group, and the difference was statistically significant(P<0.05).After treatment, FSH and LH in the two groups were lower than those of the same group before treatment, and E2was higher than that of the same group before treatment.After treatment, FSH and LH in the observation group were lower than those in the control group, and E2was higher than that in the control group.And all the differences were statistically significant(P<0.05).After treatment, EDV and PSV of the two groups were higher than those of the same group before treatment, while RI and PI were lower than those of the same group before treatment, and EDV and PSV of the observation group were higher than those of the control group, while RI and PI were lower than those of the control gr

关 键 词：卵巢储备功能低下 益肾通络方 促性腺激素释放激素拮抗剂 中西医结合疗法 

分 类 号：R271.911.75[医药卫生—中西医结合]