中西医结合疗法治疗痰湿蕴肺型变异性哮喘临床研究  

Clinical Study on the Treatment of Cough Variant Asthma with Phlegm-Dampness Accumulation in the Lung with Integrated Traditional Chinese and Western Medicine

作　　者：郑新远 ZHENG Xin-yuan(Tanghe County Hospital of Traditional Chinese Medicine,Tanghe,Henan,China,473000)

机构地区：[1]唐河县中医院,河南唐河473000

出　　处：《河南中医》2023年第2期276-280,共5页Henan Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2018ZY2014)。

摘　　要：目的:观察中西医结合疗法治疗痰湿蕴肺型变异性哮喘(cough variant asthma, CVA)的临床疗效。方法:将80例痰湿蕴肺型CVA患者按照随机数字表法分为观察组和对照组,每组各40例。对照组给予孟鲁司特钠咀嚼片口服,布地奈德福莫特罗粉吸入剂雾化吸入,观察组在对照组治疗的的基础上给予自拟健脾化痰汤治疗。比较两组患者的临床疗效、临床症状恢复时间及治疗前后肺功能[用力肺活量(forced vital capacity, FVC)、1秒用力呼吸容积(forced expiratory volume in the first second, FEV1)、FEV1/FVC]、生化指标[嗜酸性粒细胞(eosinophil, EOS)、C反应蛋白(C-reactionprotei, CRP)]变化情况。结果:观察组有效率为100.0%,对照组有效率为85.0%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后FEV1、FVC、FEV1/FVC水平高于本组治疗前,且治疗后观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后血清EOS、CRP表达水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。观察组哮喘持续时间、哮鸣音消失时间、咳嗽消失时间短于对照组,差异具有统计学意义(P<0.05)。结论:中西医结合治疗痰湿蕴肺型CVA,可改善患者的临床症状及生化指标,促进肺功能恢复正常。Objective: To observe the clinical efficacy of integrated traditional Chinese and Western medicine on cough variant asthma(CVA) with syndrome of phlegm-dampness accumulation in the lung.Methods: A total of 80 CVA patients with phlegm-dampness accumulation in the lung were randomly divided into the observation group and the control group, with 40 cases in each group.The control group was given Montelukast Sodium Chewable Tablets orally and budesonide aerosol inhalation, while the observation group was treated with self-made Spleen-Fortifying and Phlegm-Resolving Decoction on the basis of the treatment in the control group.The clinical efficacy, the recovery time of clinical symptoms and the changes of pulmonary function [including forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC)],biochemical indexes [including(eosinophil(EOS),C-reactive protein(CRP)] before and after treatment were compared between the two groups.Results: The effective rate was 100% in the observation group and 85.0% in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment, the levels of FEV1,FVC and FEV1/FVC in the two groups were higher than those of the same group before treatment, and the above levels of the observation group were higher than those of the control group, and all the differences were statistically significant(P<0.05).The expression levels of EOS and CRP in serum of the two groups after treatment were lower than those of the same group before treatment, and the above levels of the observation group were lower than those of the control group, and all the differences were statistically significant(P<0.05).The duration of asthma, the disappearance time of wheezing and cough in the observation group were shorter than those in the control group, and all the differences were statistically significant(P<0.05).Conclusion: Integrated traditional Chinese and Western medicine can improve the clinical symptoms and biochemical indicators of CVA pati

关 键 词：变异性哮喘 痰湿蕴肺证 孟鲁司特钠咀嚼片 布地奈德福莫特罗粉吸入剂 雾化吸入 健脾化痰汤 中西医结合疗法 

分 类 号：R259.622.5[医药卫生—中西医结合]