基于正交反射多次旋光效应的葡萄糖浓度传感研究  

Glucose Concentration Sensing Based on Orthogonal Reflection Multiple Polarization Rotation Effect

作　　者：李栋宇 黄贞 李超旋 张正贺 张婷婷 徐兵 金肖 王邓 刘旭萍 李清华 郑剑虹 Li Dongyu;Huang Zhen;Li Chaoxuan;Zhang Zhenghe;Zhang Tingting;Xu Bing;Jin Xiao;Wang Deng;Liu Xuping;Li Qinghua;Zheng Jianhong(Guangdong Key Laboratory of Development and Education for Special Needs Children,Zhanjiang 524048,Guangdong,China;School of Physics Science and Technology,Lingnan Normal University,Zhanjiang 524048,Guangdong,China)

机构地区：[1]广东省特殊儿童发展与教育重点实验室,广东湛江524048 [2]岭南师范学院物理科学与技术学院,广东湛江524048

出　　处：《激光与光电子学进展》2022年第21期236-241,共6页Laser & Optoelectronics Progress

基　　金：广东省自然科学基金(2022A1515012448);广东省普通高校重点科研平台和项目(2020ZDZX2055);广东省普通高校人工智能和服务乡村振兴重点领域专项(2019KZDZX2008);湛江市科技计划项目(2020A03003,2021A05042);岭南师范学院燕岭优秀青年教师培养计划资助项目(YL20200102);广东省特殊儿童发展与教育重点实验室开放基金项目(TJ202001)。

摘　　要：糖度检测在生物、医疗等领域具有关键作用。为了提高旋光法测量糖溶液浓度的分辨率,本文提出利用正交反射镜消除偏振光被金属平面镜反射后的消旋光现象,建立了参考臂和测量臂信号的相位差与溶液浓度之间的函数关系,并研究了正交反射多次旋光效应。在不增加样品长度的前提下,通过多次旋光使分辨率倍增。以葡萄糖溶液为例,四次旋光的实验结果表明:在0~0.4690 g/mL范围内,浓度测量分辨率为8×10^(−6) g/mL,最大测量相对误差小于0.54%。正交反射多次旋光检测技术可以为血糖与自闭症发病机理研究提供实时在线血糖检测。Glucose concentration measurement is crucial in various fields,including biology and medicine.This study proposes an orthogonal mirror to eliminate the 180°flipping of the polarization that generally occurs following single reflections from a metallic mirror to enhance the resolution of the polarimetry for measuring glucose concentration.The relationship between the solution concentration and the phase difference of reference light and measurement light is established.Furthermore,the effect of multiple polarization rotation based on the orthogonal mirror is explored.Multiple polarization rotation increases the glucose concentration measurement resolution without increasing the sample length.Taking glucose solution as an example,the experimental results of four rotations demonstrate that the concentration measurement resolution is 8×10^(−6) g/mL in the range of 0‒0.4690 g/mL with a maximum relative error of less than 0.54%.The proposed approach can be used for online and realtime glucose concentration detection for research on glucose abnormalities in the pathogenesis of autism spectrum disorders.

关 键 词：光谱学 旋光法 正交反射 多次旋光 葡萄糖浓度 

分 类 号：TH741[机械工程—光学工程]