醒脑静注射液联合盐酸纳美芬对急性重度酒精中毒患者氧化应激反应及神经递质水平的影响  

Effects of Xingnaojing injection combined with nalmefene hydrochloride on oxidative stress and neurotransmitter levels in patients with acute severe alcoholism

作　　者：周菁 田丽晓[2] 张丽娜 ZHOU Jing;TIAN Lixiao;ZHANG Lina(Department of Health Management,Henan Provincial People's Hospital,Zhengzhou 463599,Henan Province,China;Department of Emergency Medicine,Henan Provincial People's Hospital,Zhengzhou 463599,Henan Province,China;Department of Nephrology,Henan Provincial People's Hospital,Henan Key Laboratory of Renal Immunology,Henan Clinical Research Center of Nephropathy,Zhengzhou 463599,Henan Province,China)

机构地区：[1]河南省人民医院健康管理科,河南郑州463599 [2]河南省人民医院急诊医学科,河南郑州463599 [3]河南省人民医院肾内科,河南省肾脏病免疫重点实验室,河南省肾病临床医学研究中心,河南郑州463599

出　　处：《世界临床药物》2022年第11期1470-1474,共5页World Clinical Drug

摘　　要：目的 分析醒脑静注射液联合盐酸纳美芬对急性重度酒精中毒患者的氧化应激反应及神经递质水平的影响。方法 选择2020年2月至2021年3月河南省人民医院急诊科急性重度酒精中毒患者73例,按照抽签法分为观察组(n=38)和对照组(n=35)。对照组接受盐酸纳美芬治疗,观察组接受醒脑静注射液联合盐酸纳美芬治疗。对比两组临床治疗有效率、症状缓解时间及清醒时间、氧化应激反应[血清β-内啡肽(β-endorphin,β-EP)、丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)]变化、神经递质水平[多巴胺(dopamine,DA)、去甲肾上腺素(norepinephrine,NE)、5-羟色胺(5-hydroxytryptamin,5-HT)]变化。结果 治疗后,观察组总有效率为92.11%,显著高于对照组68.57%(P <0.05)。观察组症状缓解时间、清醒时间均短于对照组[(6.38±0.62) vs (8.35±0.81)h,(1.01±0.23) vs (1.37±0.52)h](P <0.05)。观察组β-EP、MDA水平低于对照组[(208.96±16.87) vs (237.98±15.86)ng/L,(6.08±1.32) vs (8.73±1.50)nmol/L](P <0.05),SOD水平高于对照组[(85.37±11.32) vs (67.58±10.02)kU/L](P <0.05)。观察组DA、NE、5-HT水平均低于对照组,分别为[(125.30±12.98) vs (146.23±15.36)ng/L,(232.56±19.02) vs (290.38±12.85)ng/ml,(130.75±12.60) vs(161.28±11.07)ng/L](P <0.05)。结论 醒脑静注射液联合盐酸纳美芬可有效改善急性重度酒精中毒患者的临床症状,调节氧化应激反应及神经递质水平,帮助患者恢复苏醒,临床可进一步推广。Objective To analyze the effects of Xingnaojing injection combined with nalmefene hydrochloride on oxidative stress response and neurotransmitter levels in patients with acute severe alcoholism. Methods A total of 73 patients with acute severe alcoholism in the department of emergency of Henan provincial people’s hospital from February 2020to March 2021 were selected and divided into observation group(n=38) and control group(n=35) according to the lottery method. The control group was treated with nalmefene hydrochloride, and the observation group was treated with Xingnaojing injection combined with nalmefene hydrochloride. The clinical efficacy, symptom relief time, waking time,and oxidative stress response[serum β-endorphin(β-EP), malondialdehyde(MDA), superoxide dismutase(SOD)] and neurotransmitter levels [dopamine(DA), norepinephrine(NE), and 5-hydroxytryptamin(5-HT)] were compared between the two groups. Results After treatment, the total effective rate of observation group was 92.11%, which was significantly higher than 68.57% of control group(P<0.05). The symptom relief time and waking time of the observation group were shorter than those of the control group[(6.38±0.62) vs(8.35±0.81)h,(1.01±0.23) vs(1.37±0.52)h](P<0.05). The levels of β-EP and MDA in the observation group were lower than those in the control group[(208.96±16.87) vs(237.98±15.86)ng/L,(6.08±1.32) vs(8.73±1.50)nmol/L](P<0.05). The SOD was higher than that in the control group[(85.37±11.32) vs(67.58±10.02)kU/L](P<0.05). The levels of DA, NE and 5-HT in the observation group were lower than those in the control group[(125.30±12.98) vs(146.23±15.36)ng/L,(232.56±19.02) vs(290.38±12.85)ng/ml,(130.75±12.60) vs(161.28±11.07)ng/L](P<0.05). Conclusion Xingnaojing injection combined with nalmefene hydrochloride can effectively improve the clinical symptoms of patients with acute severe alcoholism, regulate oxidative stress reaction and neurotransmitter level, and help patients recover, which can be further promoted in clinical pra

关 键 词：醒脑静注射液 盐酸纳美芬 急性重度酒精中毒 氧化应激反应 神经递质 

分 类 号：R979.3[医药卫生—药品] R595.6[医药卫生—药学]