糖基化修饰在代谢相关脂肪性肝病中作用研究进展  

Progress on glycosylation in metabolic dysfunction-associated fatty liver disease

作　　者：杨君茹 何玲玲[1] 高美欣 魏红山[1] Yang Junru;He Lingling;Gao Meixin;Wei Hongshan(Department of Gastroenterology,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院消化内科,北京100015

出　　处：《中国肝脏病杂志（电子版）》2022年第4期20-27,共8页Chinese Journal of Liver Diseases：Electronic Version

基　　金：北京市自然科学基金(7202071)。

摘　　要：代谢相关脂肪性肝病(metabolic dysfunction-associated fatty liver disease,MAFLD)居慢性肝脏疾病排名首位,影响全球约1/4人群,威胁人们健康。糖基化修饰是真核细胞蛋白质最常见的翻译后修饰之一,最近大量研究报道糖基化修饰影响脂质代谢。目前MAFLD发病机制尚未完全阐明,本文将论述较为常见的N-和O-糖基化修饰在MAFLD发病中的作用及机制。Metabolic dysfunction-associated fatty liver disease(MAFLD)is the leading cause in chronic liver diseases,affecting approximately 1/4 global people.Glycosylation is one of the most common translational or post-translational modifications of eukaryotic proteins.Recent studies have reported glycosylation regulated lipid metabolism.However,the pathogenesis of MAFLD has not been fully elucidated.Here,we review the role of common Nand O-glycosylation modifications in the pathogenesis of MAFLD.

关 键 词：代谢相关脂肪性肝病 非酒精性脂肪性肝病 糖基化修饰 己糖胺途径 磷酸戊糖途径 

分 类 号：R575.5[医药卫生—消化系统]