基于数据挖掘的《中华医典》行气利水方用药规律研究  

Study on medication rule of Xingqi Lishui Prescription in Chinese Medical Code based on data mining

作　　者：孔淼 刘成帅 宋庆桥[2] 周育平[1] KONG Miao;LIU Chengshuai;SONG Qingqiao;ZHOU Yuping(Department of Cardiology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing100053,China;Department of General,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing100053,China)

机构地区：[1]中国中医科学院广安门医院心内科,北京100053 [2]中国中医科学院广安门医院综合科,北京100053

出　　处：《中国医药导报》2023年第4期21-24,30,共5页China Medical Herald

基　　金：国家中医药管理局政府购买服务中医标准化项目(GZY-FJS-2020-214)。

摘　　要：目的探究《中华医典》行气利水方用药规律,以指导临床应用。方法通过关键词“水肿”或“水气”或“水病”,检索《中华医典》(第5版)相关条文并筛选方剂,观察指标为药物组成、性味、归经、功效、配伍关系,使用SPSS Modeler 18.0、SPSS Statistics 26.0进行频数统计、关联规则、聚类等用药规律分析。结果纳入方剂127首,药物144味;挖掘出高频药物15味,其中药物属性以苦、辛、甘、温、寒最常见,主要归肺、脾经,功效以利水渗湿、理气、补虚为主;常用配伍药物群包括木香、槟榔、葶苈子、桑白皮等;3组聚类方分别以理肺、健脾、行气为主;复杂网络分析发现28味核心药物及强链接药对一个(陈皮-桑白皮)。结论肺气郁闭、中焦气滞证为行气利水之适应证。组方谨守利水渗湿之本,肺脾同治、通调水道、健脾宽中乃行气利水枢机所在。Objective To explore the medication rule of Xingqi Lishui Prescription in Chinese Medical Code to guide clinical application.Methods The relevant provisions of the Chinese Medical Code(5th edition)were searched and prescriptions were selected by keyword“edema”or“water vapor”or“water disease”.The observed indicators were drug composition,nature,flavours,channel tropism,efficacy and concerted application relation.SPSS Modeler 18.0 and SPSS Statistics 26.0 were used for frequency statistics,association rules,clustering analysis,and other medication rule analysis.Results A total of 127 prescriptions and 144 drugs were included.Fifteen high frequency drugs were found,among which the most common drug properties were bitter,pungent,sweet,warm,and cold,which were mainly attributed to the lung and spleen channels,with the main effect of diuresis and diffusing dampness,regulating qi-flowing and tonifying deficiency.Commonly used concerted application drug groups included Aucklandiae Radix,Arecae Semen,Descurainiae Semen Lepidii Semen,Mori Cortex,and so on.The three cluster prescriptions were mainly for regulating the lung,strengthening the spleen and promoting qi.Complex network analysis found 28 core drugs and one strong link drug(Citri Reticulatae Pericarpium-Mori Cortex).Conclusion The syndrome of lung qi stagnation and middle coke qi stagnation is the indication of regulating qi and diuresis.The formula should adhere to the essence of diuresis and diffusing dampness,and the lung and spleen should be treated together,the channel should be regulated,the spleen should be strengthened and middle focal should be widened,which is the key of the regulating qi and diuresis.

关 键 词：中医 水肿 行气 数据挖掘 用药规律 

分 类 号：R285[医药卫生—中药学]