基于肠道菌群探讨中药治疗溃疡性结肠炎的研究进展  

Research progress of treating ulcerative colitis with traditional Chinese medicine based on intestinal flora

作　　者：房子铭 孙志文 谢晶日[2] FANG Ziming;SUN Zhiwen;XIE Jingri(Graduate School,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Department of Gastroenterology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院肝脾胃科,黑龙江哈尔滨150040

出　　处：《中国医药导报》2023年第6期42-45,58,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81273685);国家中医药管理局全国名老中医专家传承工作室建设项目(国中医药人教发〔2016〕42号);黑龙江省博士后资助项目(LBH-Z20194)。

摘　　要：溃疡性结肠炎(UC)是一种影响肠道的慢性免疫性介导疾病,其病程迁延,复发率高,缺乏有效的治疗手段,影响患者的健康。近年来,UC患者日益增多,受到广泛关注,但其病因与发病机制仍未明确。越来越多研究表明,肠道微生态失衡是UC的一个重要致病机制,中药能够通过调节肠道微生态平衡,增强肠道微生物屏障稳定性、提高肠道免疫功能发挥治疗UC的作用。本文主要从中药单体、复方调节肠道微生物群治疗UC的研究进展作一综述,为进一步治疗UC提供参考。Ulcerative colitis(UC)is a chronic immune-mediated disease affecting the intestinal tract.Its course is prolonged,the recurrence rate is high,and the lack of effective treatment affects the health of patients.In recent years,the number of UC patients has been increasing,which has attracted wide attention,but its etiology and pathogenesis remain unclear.More and more studies have shown that intestinal microecological imbalance is an important pathogenic mechanism of UC.Traditional Chinese medicine can play a role in the treatment of UC by regulating intestinal microecological balance,enhancing the stability of intestinal microbial barrier and improving intestinal immune function.This article mainly reviews the research progress of the regulation of intestinal microbiome by traditional Chinese medicine monomer and compound in the treatment of UC,and provides reference for further treatment of UC.

关 键 词：溃疡性结肠炎 肠道菌群 中医药 机制 

分 类 号：R28[医药卫生—中药学]