基于数据挖掘的痰瘀同治法治疗动脉粥样硬化的用药规律  

Medication laws of simultaneous treatment for phlegm and blood stasis in treating atherosclerosis based on data mining

作　　者：吴茜 李兰兰 曹琳琳 王师菡[1] WU Qian;LI Lanlan;CAO Linlin;WANG Shihan(Department of Cardiovascular,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing100053,China)

机构地区：[1]中国中医科学院广安门医院心血管科,北京100053

出　　处：《中国医药导报》2023年第6期119-122,144,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81473465);首都临床诊疗技术研究及示范应用项目(Z191100006619025)。

摘　　要：目的探讨基于数据挖掘的痰瘀同治法治疗动脉粥样硬化的用药规律。方法检索2012年1月至2022年3月中国知网、万方数据库、维普网的文献,建立方药数据库,整理药物功效、四气、五味、归经用药规律,开展关联规则、聚类分析及复杂网络分析。结果按照纳入及排除标准进行筛选,最终纳入中药处方63首,中药124味,痰瘀同治法的用药以活血化瘀药、补虚药、化痰止咳平喘药为主,最常用的药味为苦味、药性为温性,归经以肝、肺、胃经居多。高频中药的关联规则分析、聚类分析分别形成15组药对组合、7类聚类组合。复杂网络分析提示痰瘀同治法抗动脉粥样硬化的核心处方为丹蒌片合二陈汤加减。结论痰瘀同治法治疗动脉粥样硬化以活血化痰为基础,兼以扶正补虚、清利消导增化痰祛瘀之功。Objective To discuss the medication laws of simultaneous treatment for phlegm and blood stasis in treating atherosclerosis based on data mining.Methods The literatures of CNKI,Wanfang Data and VIP from January 2012 to March 2022 were retrieved.The prescription database was established.The drug efficacy,four nature,five flavors,and channel tropism medication laws had been sorted out.Association rules,cluster analysis,and complex network analysis were carried out.Results According to the inclusion and exclusion criteria,63 prescriptions of traditional Chinese medicine and 124 flavors of traditional Chinese medicine were finally included.The drugs for the treatment of phlegm and blood stasis were mainly drugs for promoting blood circulation and resolving blood stasis,drugs for tonifying deficiency,and drugs for dissipating phlegm,relieving cough and asthma.The most commonly used medicine was bitter,and its nature was warm.The liver,lung and stomach channel were the main channel tropism.The association rule analysis and cluster analysis of high-frequency traditional Chinese medicine had formed 15 drug pair combinations and seven cluster combinations.The complex network analysis suggested that the core prescription of the treatment of phlegm and blood stasis was Danlou Tablets and Erchen Decoction plus or minus.Conclusion The basic means of simultaneous treatment for phlegm and blood stasis to treat atherosclerosis is activating blood and dissipating phlegm,combining with strengthen vital qi and tonify the deficiency,clear heat-dampness and promote digestion to enhance the effect of dissipating phlegm and removing blood stasis.

关 键 词：动脉粥样硬化 痰瘀同治 数据挖掘 

分 类 号：R256.2[医药卫生—中医内科学]